For research use only. Not for therapeutic Use.
T0467（Cat No.:I044424）is a small-molecule inhibitor that targets the Wnt/β-catenin signaling pathway, a key regulator of cell proliferation, differentiation, and stem cell maintenance. By interfering with β-catenin-mediated transcription, T0467 suppresses the expression of Wnt target genes involved in tumor growth and survival. It is particularly useful in cancer research, especially for malignancies exhibiting aberrant Wnt signaling such as colorectal, liver, and breast cancers. T0467 aids in dissecting Wnt pathway dynamics and supports the development of therapeutic strategies aimed at modulating this pathway in oncology and regenerative medicine.
| CAS Number | 859518-94-8 |
| Synonyms | N-[2-(3,5-difluorophenyl)ethyl]-4-[2-fluoro-5-[[(2S)-2-methylpiperazin-1-yl]methyl]phenyl]pyrimidin-2-amine |
| Molecular Formula | C24H26F3N5 |
| Purity | ≥95% |
| IUPAC Name | N-[2-(3,5-difluorophenyl)ethyl]-4-[2-fluoro-5-[[(2S)-2-methylpiperazin-1-yl]methyl]phenyl]pyrimidin-2-amine |
| InChI | InChI=1S/C24H26F3N5/c1-16-14-28-8-9-32(16)15-18-2-3-22(27)21(12-18)23-5-7-30-24(31-23)29-6-4-17-10-19(25)13-20(26)11-17/h2-3,5,7,10-13,16,28H,4,6,8-9,14-15H2,1H3,(H,29,30,31)/t16-/m0/s1 |
| InChIKey | GNYKYGZGDGZPOK-INIZCTEOSA-N |
| SMILES | C[C@H]1CNCCN1CC2=CC(=C(C=C2)F)C3=NC(=NC=C3)NCCC4=CC(=CC(=C4)F)F |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
