Syrosingopine

• CAT Number: I010174
• CAS Number: 84-36-6
• Molecular Formula: C₃₅H₄₂N₂O₁₁
• Molecular Weight: 666.72
• Purity: ≥95%
• Storage: Store at -20°C
• IUPAC Name: methyl (1R,15S,17R,18R,19S,20S)-17-(4-ethoxycarbonyloxy-3,5-dimethoxybenzoyl)oxy-6,18-dimethoxy-1,3,11,12,14,15,16,17,18,19,20,21-dodecahydroyohimban-19-carboxylate
• InChI: InChI=1S/C35H42N2O11/c1-7-46-35(40)48-31-26(42-3)12-18(13-27(31)43-4)33(38)47-28-14-19-17-37-11-10-22-21-9-8-20(41-2)15-24(21)36-30(22)25(37)16-23(19)29(32(28)44-5)34(39)45-6/h8-9,12-13,15,19,23,25,28-29,32,36H,7,10-11,14,16-17H2,1-6H3/t19-,23+,25-,28-,29+,32+/m1/s1
• InChIKey: ZCDNRPPFBQDQHR-SSYATKPKSA-N
• SMILES: CCOC(=O)OC1=C(C=C(C=C1OC)C(=O)OC2CC3CN4CCC5=C(C4CC3C(C2OC)C(=O)OC)NC6=C5C=CC(=C6)OC)OC

Syrosingopine（Cat No.:I010174）, is a chemical compound that was once used in combination with another drug, ouabain, for experimental purposes in cardiovascular research. This combination was used to study the effects of sodium-potassium pumps in cardiac cells and their potential relevance to hypertension and heart disease. However, syrosingopine is not approved for medical use in most countries and is not commonly prescribed. It is primarily known for its historical significance in scientific research rather than its practical clinical applications.

Reference

1: Furukawa T, Sano T, Kohno Y, Koga M, Nagasaki N. Selective depleting effect of
syrosingopine on brain catecholamine levels with relation to morphine analgesia
in the rat. Pharmacol Biochem Behav. 1976 Apr;4(4):419-25. PubMed PMID: 6976.
2: Agarwel SL, Bhargava V, Jadhav JH. Effect of syrosingopine on the
acetylcholine content in albino rats. Indian J Physiol Pharmacol. 1966
Oct;10(4):166-7. PubMed PMID: 4384035.
3: CHIDSEY CA, FRYE RL, KAHLER RL, BRAUNWALD E. Influence of syrosingopine on the
cardiovascular response to acute hypoxemia and exercise. Circ Res. 1961
Sep;9:989-95. PubMed PMID: 13878933.
4: BARTELS CC. Syrosingopine: a new rauwolfia preparation. N Engl J Med. 1959 Oct
15;261:785-8. PubMed PMID: 13797201.
5: HERRMANN GR, VOGELPOHL EB, HEJTMANCIK MR, WRIGHT JC. Therapy of hypertension
with orally given syrosingopine. J Am Med Assoc. 1959 Apr 4;169(14):1609-12.
PubMed PMID: 13640910.