For research use only. Not for therapeutic Use.
SW2_110A（Cat No.:I036876）is a potent, selective inhibitor targeting the SWI/SNF chromatin remodeling complex subunit BRM (SMARCA2). It modulates ATPase activity, disrupting nucleosome positioning and altering gene expression patterns in cancer cells dependent on BRM for survival. This compound is valuable in studying synthetic lethality, particularly in tumors lacking BRG1 (SMARCA4). SW2_110A has been applied in preclinical research for assessing epigenetic vulnerabilities in oncology. Its high selectivity and cell-permeable nature make it suitable for both biochemical assays and cell-based experiments exploring chromatin regulation mechanisms.
| CAS Number | 2579696-95-8 |
| Synonyms | N-[(1S)-1-cyclopentyl-2-[[(2R,3S)-1-[[(2S)-6-(diethylamino)-1-[[(2S)-3-hydroxy-1-oxo-1-(prop-2-ynylamino)propan-2-yl]amino]-1-oxohexan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]-4-phenoxybenzamide |
| Molecular Formula | C42H60N6O7 |
| Purity | ≥95% |
| IUPAC Name | N-[(1S)-1-cyclopentyl-2-[[(2R,3S)-1-[[(2S)-6-(diethylamino)-1-[[(2S)-3-hydroxy-1-oxo-1-(prop-2-ynylamino)propan-2-yl]amino]-1-oxohexan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]-4-phenoxybenzamide |
| InChI | InChI=1S/C42H60N6O7/c1-6-26-43-39(51)35(28-49)45-40(52)34(21-15-16-27-48(8-3)9-4)44-41(53)36(29(5)7-2)46-42(54)37(30-17-13-14-18-30)47-38(50)31-22-24-33(25-23-31)55-32-19-11-10-12-20-32/h1,10-12,19-20,22-25,29-30,34-37,49H,7-9,13-18,21,26-28H2,2-5H3,(H,43,51)(H,44,53)(H,45,52)(H,46,54)(H,47,50)/t29-,34-,35-,36+,37-/m0/s1 |
| InChIKey | HEDLPSLAOJYDMT-GUKRFWIHSA-N |
| SMILES | CC[C@H](C)[C@H](C(=O)N[C@@H](CCCCN(CC)CC)C(=O)N[C@@H](CO)C(=O)NCC#C)NC(=O)[C@H](C1CCCC1)NC(=O)C2=CC=C(C=C2)OC3=CC=CC=C3 |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
