3,3’,5-Triiodo-L-thyronine

• CAT Number: R000993
• CAS Number: 6893-02-3
• Molecular Formula: C15H12I3NO4
• Molecular Weight: 650.977
• Purity: ≥95%
• Storage: Store at RT
• IUPAC Name: (2S)-2-amino-3-[4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl]propanoic acid
• InChI: InChI=1S/C15H12I3NO4/c16-9-6-8(1-2-13(9)20)23-14-10(17)3-7(4-11(14)18)5-12(19)15(21)22/h1-4,6,12,20H,5,19H2,(H,21,22)/t12-/m0/s1
• InChIKey: AUYYCJSJGJYCDS-LBPRGKRZSA-N
• SMILES: C1=CC(=C(C=C1OC2=C(C=C(C=C2I)CC(C(=O)O)N)I)I)O

Triiodothyronine (Cat No.:R000993) is a thyroid hormone that affects various physiological processes in the human body, including growth and development, metabolism, body temperature and heart rate, etc. T3 has a role in promoting material metabolism and energy release; it also promotes growth and development.

Reference

1:3, 3/’, 5-triiodo-L-thyronine Increases In Vitro Chondrogenesis of Mesenchymal Stem Cells From Human Umbilical Cord Stroma Through SRC2. Fernández-Pernas P, Fafián-Labora J, Lesende-Rodriguez I, Mateos J, De la Fuente A, Fuentes I, De Toro Santos J, Blanco García F, Arufe MC.J Cell Biochem. 2016 Sep;117(9):2097-108. doi: 10.1002/jcb.25515. Epub 2016 Mar 30. PMID: 26869487 2:Anti-Apoptotic Effects of 3,3/’,5-Triiodo-L-Thyronine in the Liver of Brain-Dead Rats. Rebolledo RA, Van Erp AC, Ottens PJ, Wiersema-Buist J, Leuvenink HG, Romanque P.PLoS One. 2015 Oct 5;10(10):e0138749. doi: 10.1371/journal.pone.0138749. eCollection 2015. PMID: 26437380 Free PMC Article3:Characterization of little skate (Leucoraja erinacea) recombinant transthyretin: Zinc-dependent 3,3/’,5-triiodo-l-thyronine binding. Suzuki S, Kasai K, Yamauchi K.Gen Comp Endocrinol. 2015 Jun-Jul;217-218:43-53. doi: 10.1016/j.ygcen.2015.04.006. Epub 2015 Apr 9. PMID: 25863347 4:Monocrotophos pesticide decreases the plasma levels of total 3,3/’,5-triiodo-l-thyronine and alters the expression of genes associated with the thyroidal axis in female goldfish (Carassius auratus). Zhang X, Tian H, Wang W, Ru S.PLoS One. 2014 Sep 30;9(9):e108972. doi: 10.1371/journal.pone.0108972. eCollection 2014. PMID: 25268935 Free PMC Article5:3,3/’,5-Triiodo-L-thyronine-like activity in effluents from domestic sewage treatment plants detected by in vitro and in vivo bioassays. Murata T, Yamauchi K.Toxicol Appl Pharmacol. 2008 Feb 1;226(3):309-17. Epub 2007 Sep 16. PMID: 17949767 6:The influence of 3,3/’,5-triiodo-L-thyronine on human haematopoiesis. Grymuła K, Paczkowska E, Dziedziejko V, Baśkiewicz-Masiuk M, Kawa M, Baumert B, Celewicz Z, Gawrych E, Machaliński B.Cell Prolif. 2007 Jun;40(3):302-15. PMID: 17531076 7:3,3/’,5-Triiodo-L-thyronine inhibits ductal pancreatic adenocarcinoma proliferation improving the cytotoxic effect of chemotherapy. Michienzi S, Bucci B, Verga Falzacappa C, Patriarca V, Stigliano A, Panacchia L, Brunetti E, Toscano V, Misiti S.J Endocrinol. 2007 May;193(2):209-23. PMID: 17470512 Free Article8:Alterations in expression of senescence marker protein-30 gene by 3,3/’,5-triiodo-L-thyronine (T3). Sar P, Rath B, Subudhi U, Chainy GB, Supakar PC.Mol Cell Biochem. 2007 Sep;303(1-2):239-42. Epub 2007 Apr 11. PMID: 17426926 9:3,3/’,5-Triiodo-L-thyronine up-regulation of Na,K-ATPase activity and cell surface expression in alveolar epithelial cells is Src kinase- and phosphoinositide 3-kinase-dependent. Lei J, Mariash CN, Ingbar DH.J Biol Chem. 2004 Nov 12;279(46):47589-600. Epub 2004 Aug 31. PMID: 15342623 Free Article10:Determination of (+)-3,3/’,5-triiodo-L-thyronine (L-T3) from serum using a sequential injection analysis/immunosensor system. Stefan RI, van Staden JF, Aboul-Enein HY.J Immunoassay Immunochem. 2004;25(2):183-9. PMID: 15162921