Supinoxin (RX-5902)

• CAT Number: I009651
• CAS Number: 888478-45-3
• Molecular Formula: C22H24FN5O4
• Molecular Weight: 441.46
• Purity: ≥95%
• Synonyms: Supinoxin; RX5902; RX5902; RX 5902.;4-(3,5-dimethoxyphenyl)-N-(7-fluoro-3-methoxyquinoxalin-2-yl)piperazine-1-carboxamide
• Target: p68 RNA helicase inhibitor
• Solubility: Soluble in DMSO, not in water
• Storage: 0 - 4°C for short term , or -20°C for long term.
• SMILES: O=C(N1CCN(C2=CC(OC)=CC(OC)=C2)CC1)NC3=NC4=CC(F)=CC=C4N=C3OC

Supinoxin (RX-5902)(CAT: I009651) is an orally bioavailable small molecule inhibitor that specifically targets phosphorylated-p68 RNA helicase (P-p68). It exhibits potential anti-proliferative and antineoplastic activities. By inhibiting P-p68, Supinoxin may have a dual effect on tumor cells. It can inhibit the activity of the anti-apoptotic protein B-cell lymphoma 2 (Bcl-2) and facilitate the induction of cyclin-dependent kinase inhibitor 1 (p21). These actions can prevent G2/M cell cycle progression and result in growth inhibition in tumor cells. P-p68 is known to be overexpressed in various solid tumors while being absent in normal tissues. Its inhibition by Supinoxin holds promise in targeting tumor progression and metastasis.

Reference

1: Kost GC, Yang MY, Li L, Zhang Y, Liu CY, Kim DJ, Ahn CH, Lee YB, Liu ZR. A Novel Anti-Cancer Agent, 1-(3,5-Dimethoxyphenyl)-4-[(6-fluoro-2-methoxyquinoxalin-3-yl)aminocarbonyl] piperazine (RX-5902),Interferes with β-Catenin Function through Y593 phospho-p68RNA Helicase. J Cell Biochem. 2015 Feb 3. doi: 10.1002/jcb.25113. [Epub ahead of print] PubMed PMID: 25649741.