• CAT Number: I036848
  • CAS Number: 2377881-92-8
  • Molecular Formula: C29H28O8S2
  • Molecular Weight: 568.655
  • Purity: 98%
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MSA-2 dimer is an oral non-nucleotide STING agonist with nanomolar affinity (Kd = 145 μM). It binds to STING as a non-covalent dimer and has long-term antitumor and immunogenic activity. MSA-2 dimer has higher permeability than cyclic dinucleotide, making it a promising candidate for cancer immunotherapy.

Catalog Number I036848
CAS Number 2377881-92-8

SUN81928; SUN-81928; SUN 81928;

Molecular Formula


Purity 98
Solubility To be determined
Storage Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
IUPAC Name 4,4'-(propane-1,3-diylbis(6-methoxybenzo[b]thiophene-5,2-diyl))bis(4-oxobutanoic acid)
InChI InChI=1S/C29H28O8S2/c1-36-22-14-24-18(12-26(38-24)20(30)6-8-28(32)33)10-16(22)4-3-5-17-11-19-13-27(21(31)7-9-29(34)35)39-25(19)15-23(17)37-2/h10-15H,3-9H2,1-2H3,(H,32,33)(H,34,35)

Pan BS, Perera SA, Piesvaux JA, Presland JP, Schroeder GK, Cumming JN, Trotter BW, Altman MD, Buevich AV, Cash B, Cemerski S, Chang W, Chen Y, Dandliker PJ, Feng G, Haidle A, Henderson T, Jewell J, Kariv I, Knemeyer I, Kopinja J, Lacey BM, Laskey J, Lesburg CA, Liang R, Long BJ, Lu M, Ma Y, Minnihan EC, O’Donnell G, Otte R, Price L, Rakhilina L, Sauvagnat B, Sharma S, Tyagarajan S, Woo H, Wyss DF, Xu S, Bennett DJ, Addona GH. An orally available non-nucleotide STING agonist with antitumor activity. Science. 2020 Aug 21;369(6506):eaba6098. doi: 10.1126/science.aba6098. PMID: 32820094.

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