Strontium Ranelate

• CAT Number: A000439
• CAS Number: 135459-87-9
• Molecular Formula: C12H6N2O8SSr2
• Molecular Weight: 513.49
• Purity: ≥95%
• Target: Calcium Channel
• Solubility: Limited solubility
• Storage: -20°C
• InChI: 1S/C12H10N2O8S.2Sr/c13-2-6-5(1-7(15)16)10(12(21)22)23-11(6)14(3-8(17)18)4-9(19)20;;/h1,3-4H2,(H,15,16)(H,17,18)(H,19,20)(H,21,22);;/q;2*+2/p-4
• InChIKey: XXUZFRDUEGQHOV-UHFFFAOYSA-J
• SMILES: C(C1=C(SC(=C1C#N)N(CC(=O)[O-])CC(=O)[O-])C(=O)[O-])C(=O)[O-].[Sr+2].[Sr+2]

Strontium Ranelate is a strontium(II) salt of ranelic acid, is a medication for osteoporosis. Studies indicate it can also slow the course of osteoarthritis of the knee. The drug is unusual in that it both increases deposition of new bone by osteoblasts and reduces the resorption of bone by osteoclasts. It is therefore promoted as a /dual action bone agent/ (DABA). The use is now restricted to treatment of severe osteoporosis in postmenopausal women at high risk for fracture.

Reference

1: Lavet C, Mabilleau G, Chappard D, Rizzoli R, Ammann P. Strontium ranelate
stimulates trabecular bone formation in a rat tibial bone defect healing process.
Osteoporos Int. 2017 Sep 28. doi: 10.1007/s00198-017-4156-3. [Epub ahead of
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2: Masalskas BF, Martins Júnior W, Leoni GB, Faloni APS, Marcaccini AM, Silva
Sousa YTC, Castro-Raucci LMS. Local delivery of strontium ranelate promotes
regeneration of critical size bone defects filled with collagen sponge. J Biomed
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3: Strontium ranelate discontinued. Drug Ther Bull. 2017 Aug;55(8):93-94. doi:
10.1136/dtb.2017.8.0516. PubMed PMID: 28808083.

4: Rodrigues TA, Sampaio AJB Junior, Nunes IDP, Cartágenes MSS, Garcia JBS.
Effect of strontium ranelate on pain behavior in an experimental model of
osteoarthritis. Braz J Med Biol Res. 2017 Aug 7;50(9):e6314. doi:
10.1590/1414-431X20176314. PubMed PMID: 28793056; PubMed Central PMCID:
PMC5572847.

5: ▽ Strontium ranelate discontinued. Drug Ther Bull. 2017 Aug 2. doi:
10.1136/dtb.2017.8.0507. [Epub ahead of print] PubMed PMID: 28768695.

6: Pan WL, Chen PL, Lin CY, Pan YC, Ju YR, Chan CP, Hsu RW. Strontium ranelate
treatment in a postmenopausal woman with osteonecrosis of the jaw after long-term
oral bisphosphonate administration: a case report. Clin Interv Aging. 2017 Jul
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7: Pineyro MM, Arrestia D, Elhordoy M, Lima R, Wajskopf S, Pisabarro R, Serra MP.
Spontaneous reossification of the sella in transsphenoidal reoperation associated
with strontium ranelate. Endocrinol Diabetes Metab Case Rep. 2017 Jul 7;2017.
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PubMed Central PMCID: PMC5510395.

8: Moreno-Higueras M, Callejas-Rubio JL, Gallo-Padilla L. Dress syndrome and
bilateral panuveitis caused by strontium ranelate. Med Clin (Barc). 2017 Oct
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Spanish. PubMed PMID: 28662886.

9: Alves SM, Abreu SC, Lemos JC, Gomes FIF, Alves SM, do Val DR, Freitas RS,
Pereira KMA, de Paulo Teixeira Pinto V, de Castro Brito GA, Bezerra MM,
Cristino-Filho G, Chaves HV. Anti-inflammatory and anti-nociceptive effects of
strontium ranelate on the zymosan-induced temporomandibular joint inflammatory
hypernociception in rats depend on TNF-α inhibition. Pharmacol Rep. 2017
Aug;69(4):764-772. doi: 10.1016/j.pharep.2017.03.007. Epub 2017 Mar 12. PubMed
PMID: 28587937.

10: Pilmane M, Salma-Ancane K, Loca D, Locs J, Berzina-Cimdina L. Strontium and
strontium ranelate: Historical review of some of their functions. Mater Sci Eng C
Mater Biol Appl. 2017 Sep 1;78:1222-1230. doi: 10.1016/j.msec.2017.05.042. Epub
2017 May 9. Review. PubMed PMID: 28575961.