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Streptozocin

Streptozocin

  • CAT Number: I013934
  • CAS Number: 18883-66-4
  • Molecular Formula: C₈H₁₅N₃O₇
  • Molecular Weight: 265.22
  • Purity: ≥95%
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Streptozocin is a potent DNA-methylating agent, with IC50 values of 11.7, 904 and 1024 μg/mL for HL60, K562 and C1498 cells respectively.

Catalog Number I013934
CAS Number 18883-66-4
Molecular Formula

C₈H₁₅N₃O₇

Purity 95%
Target DNA/RNA Synthesis DNA Alkylator/Crosslinker
Solubility DMSO: ≥ 30 mg/mL; H2O: 113.3 mg/mL (Need ultrasonic and warming)
IUPAC Name 1-methyl-1-nitroso-3-[(2S,4S,5S)-2,4,5-trihydroxy-6-(hydroxymethyl)oxan-3-yl]urea
InChI InChI=1S/C8H15N3O7/c1-11(10-17)8(16)9-4-6(14)5(13)3(2-12)18-7(4)15/h3-7,12-15H,2H2,1H3,(H,9,16)/t3?,4?,5-,6+,7+/m1/s1
InChIKey ZSJLQEPLLKMAKR-FEQHFJGESA-N
SMILES CN(C(=O)NC1C(C(C(OC1O)CO)O)O)N=O
Reference

[1]. Bennett RA, et al. Alkylation of DNA in rat tissues following administration of streptozotocin. Cancer Res. 1981 Jul;41(7):2786-90.<br><br>[2]. Diab RA, et al. Immunotoxicological effects of streptozotocin and alloxan: in vitro and in vivo studies. Immunol Lett. 2015 Feb;163(2):193-8.<br><br>[3]. Acer S, et al. Oxidative stress of crystalline lens in rat menopausal model. Arq Bras Oftalmol. 2016 Jul-Aug;79(4):222-5.

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