Stiripentol

• CAT Number: R003209
• CAS Number: 49763-96-4
• Molecular Formula: C14H18O3
• Molecular Weight: 234.3
• Purity: 98%
• Target: Dehydrogenase
• Solubility: >9.9mg/mL in DMSO
• Storage: Store at -20°C
• IUPAC Name: (E)-1-(1,3-benzodioxol-5-yl)-4,4-dimethylpent-1-en-3-ol
• InChI: InChI=1S/C14H18O3/c1-14(2,3)13(15)7-5-10-4-6-11-12(8-10)17-9-16-11/h4-8,13,15H,9H2,1-3H3/b7-5+
• InChIKey: IBLNKMRFIPWSOY-FNORWQNLSA-N

Stiripentol(cas 49763-96-4) is an LDH inhibitor. It is a new-generation antiepileptic drug, and its chemical structure is unrelated to other antiepileptic drugs. Seizures and epileptiform activity are reduced by inhibition of the metabolic pathway via lactate dehydrogenase (LDH), which is a component of the astrocyte-neuron lactate shuttle

Reference

1: Klein P, Tolbert D, Gidal BE. Drug-drug interactions and pharmacodynamics of
concomitant clobazam and cannabidiol or stiripentol in refractory seizures.
Epilepsy Behav. 2019 Sep 10:106459. doi: 10.1016/j.yebeh.2019.106459. [Epub ahead
of print] PubMed PMID: 31519475.

2: Wyatt CM, Drüeke TB. Stiripentol for the treatment of primary hyperoxaluria
and calcium oxalate nephropathy. Kidney Int. 2019 Aug 23. pii:
S0085-2538(19)30687-8. doi: 10.1016/j.kint.2019.06.011. [Epub ahead of print]
PubMed PMID: 31451300.

3: Assimos DG. Re: Stiripentol Protects against Calcium Oxalate Nephrolithiasis
and Ethylene Glycol Poisoning. J Urol. 2019 Jul 31:10109701JU0000579360863224f.
doi: 10.1097/01.JU.0000579360.86322.4f. [Epub ahead of print] PubMed PMID:
31364941.

4: Yamamoto Y, Takahashi Y, Ikeda H, Imai K, Kagawa Y, Inoue Y. Impact of CYP2C19
phenotypes on clinical efficacy of stiripentol in Japanese patients with Dravet
syndrome. Ther Drug Monit. 2019 Jul 15. doi: 10.1097/FTD.0000000000000676. [Epub
ahead of print] PubMed PMID: 31318844.

5: Buck ML, Goodkin HP. Stiripentol: A Novel Antiseizure Medication for the
Management of Dravet Syndrome. Ann Pharmacother. 2019 Nov;53(11):1136-1144. doi:
10.1177/1060028019856008. Epub 2019 Jun 6. PubMed PMID: 31167540.