Stat3 Inhibitor I, S3I-201

• CAT Number: I003766
• CAS Number: 501919-59-1
• Molecular Formula: C₁₆H₁₅NO₇S
• Molecular Weight: 365.36
• Purity: ≥95%
• Target: STAT
• Solubility: DMSO: ≤ 25 mg/mL
• Storage: 3 years -20℃ powder
• IC50: 86 uM
• IUPAC Name: 2-hydroxy-4-[[2-(4-methylphenyl)sulfonyloxyacetyl]amino]benzoic acid
• InChI: InChI=1S/C16H15NO7S/c1-10-2-5-12(6-3-10)25(22,23)24-9-15(19)17-11-4-7-13(16(20)21)14(18)8-11/h2-8,18H,9H2,1H3,(H,17,19)(H,20,21)
• InChIKey: HWNUSGNZBAISFM-UHFFFAOYSA-N
• SMILES: CC1=CC=C(C=C1)S(=O)(=O)OCC(=O)NC2=CC(=C(C=C2)C(=O)O)O

Stat3 Inhibitor I (Cat.No:I003766), also known as S3I-201 (CAS 501919-59-1), is a small molecule inhibitor of signal transducer and activator of transcription 3 (Stat3). Stat3 is involved in cell growth, survival, and immune responses, making it an attractive target in cancer therapy. S3I-201 has shown promise in preclinical studies as an anticancer agent with potential therapeutic applications.

Reference

1:NSC 74859 enhances doxorubicin cytotoxicity via inhibition of epithelial-mesenchymal transition in hepatocellular carcinoma cells. Hu QD, Chen W, Yan TL, Ma T, Chen CL, Liang C, Zhang Q, Xia XF, Liu H, Zhi X, Zheng XX, Bai XL, Yu XZ, Liang TB.Cancer Lett. 2012 Dec 28;325(2):207-13. doi: 10.1016/j.canlet.2012.07.003. Epub 2012 Jul 7. PMID: 22781398
2:NSC 74859-mediated inhibition of STAT3 enhances the anti-proliferative activity of cetuximab in hepatocellular carcinoma. Chen W, Shen X, Xia X, Xu G, Ma T, Bai X, Liang T.Liver Int. 2012 Jan;32(1):70-7. doi: 10.1111/j.1478-3231.2011.02631.x. Epub 2011 Sep 6. PMID: 22098470
3:The STAT3 inhibitor NSC 74859 is effective in hepatocellular cancers with disrupted TGF-beta signaling. Lin L, Amin R, Gallicano GI, Glasgow E, Jogunoori W, Jessup JM, Zasloff M, Marshall JL, Shetty K, Johnson L, Mishra L, He AR.Oncogene. 2009 Feb 19;28(7):961-72. doi: 10.1038/onc.2008.448. Epub 2009 Jan 12. PMID: 19137011 Free PMC Article