Stachydrine

• CAT Number: I013688
• CAS Number: 471-87-4
• Molecular Formula: C₇H₁₃NO₂
• Molecular Weight: 143.18
• Purity: ≥95%
• Target: NF-κB
• Solubility: H2O: ≥ 32 mg/mL; DMSO: ≥ 26 mg/mL
• Storage: 2-8°C
• IUPAC Name: (2S)-1,1-dimethylpyrrolidin-1-ium-2-carboxylate
• InChI: InChI=1S/C7H13NO2/c1-8(2)5-3-4-6(8)7(9)10/h6H,3-5H2,1-2H3/t6-/m0/s1
• InChIKey: CMUNUTVVOOHQPW-LURJTMIESA-N
• SMILES: C[N+]1(CCCC1C(=O)[O-])C

Stachydrine（Cat No.:I013688） is a prominent component found in the Chinese herb Leonurus heterophyllus sweet, commonly used to enhance blood circulation and alleviate blood stasis. It has been found to possess inhibitory effects on the NF-κB signal pathway. By inhibiting this signaling pathway, stachydrine may have potential anti-inflammatory properties and contribute to the regulation of immune responses.

Reference

[1]. Guo W, et al. Effect of Leonurus stachydrine on myocardial cell hypertrophy. Zhong Yao Cai. 2012 Jun;35(6):940-3.[2]. Yin J, et al. Stachydrine, a major constituent of the Chinese herb leonurus heterophyllus sweet, ameliorates human umbilical vein endothelial cells injury induced by anoxia-reoxygenation. Am J Chin Med. 2010;38(1):157-71.[3]. Rathee P, et al. In vitro anticancer activity of stachydrine isolated from Capparis decidua on prostate cancer cell lines. Nat Prod Res. 2012;26(18):1737-40.[4]. Zhang C, et al. Effects of stachydrine on norepinephrine-induced neonatal rat cardiac myocytes hypertrophy and intracellular calcium transients. BMC Complement Altern Med. 2014 Dec 8;14:474.[5]. Zhang C, et al. Effect of stachydrine on endoplasmic reticulum stress-induced apoptosis in rat kidney after unilateral ureteral obstruction. J Asian Nat Prod Res. 2013;15(4):373-81.