ST-193

• CAT Number: I013668
• CAS Number: 489416-12-8
• Molecular Formula: C₂₄H₂₅N₃O
• Molecular Weight: 371.47
• Purity: ≥95%
• Target: Arenavirus
• Solubility: DMSO: ≥ 150 mg/mL
• Storage: Store at -20°C
• IUPAC Name: 1-(4-methoxyphenyl)-N-[(4-propan-2-ylphenyl)methyl]benzimidazol-5-amine
• InChI: InChI=1S/C24H25N3O/c1-17(2)19-6-4-18(5-7-19)15-25-20-8-13-24-23(14-20)26-16-27(24)21-9-11-22(28-3)12-10-21/h4-14,16-17,25H,15H2,1-3H3
• InChIKey: JPSZEXYTKSIPDW-UHFFFAOYSA-N
• SMILES: CC(C)C1=CC=C(C=C1)CNC2=CC3=C(C=C2)N(C=N3)C4=CC=C(C=C4)OC

ST-193（Cat No.:I013668） is a potent and broad-spectrum inhibitor of arenaviruses. It exhibits remarkable antiviral activity against multiple arenaviruses, with IC50 values of 0.44 nM for the Guanarito virus, 0.62 nM for the Junin virus, 1.4 nM for the Lassa virus, and 3.1 nM for the Machupo virus. This indicates its efficacy in inhibiting the replication and spread of these viruses.

Reference

[1]. Burgeson JR, et al. Discovery and optimization of potent broad-spectrum arenavirus inhibitors derived from benzimidazole and related heterocycles. Bioorg Med Chem Lett. 2013 Feb 1;23(3):750-6. [2]. Larson RA, et al. Identification of a broad-spectrum arenavirus entry inhibitor. J Virol. 2008 Nov;82(21):10768-75.[3]. Cashman KA, et al. Evaluation of Lassa antiviral compound ST-193 in a guinea pig model. Antiviral Res. 2011 Apr;90(1):70-9.