SRS11-92

• CAT Number: I045555
• CAS Number: 1467047-25-1
• Molecular Formula: C22H28N2O2
• Molecular Weight: 352.47
• Purity: ≥95%
• Synonyms: ethyl 3-(benzylamino)-4-(cyclohexylamino)benzoate
• InChI: InChI=1S/C22H28N2O2/c1-2-26-22(25)18-13-14-20(24-19-11-7-4-8-12-19)21(15-18)23-16-17-9-5-3-6-10-17/h3,5-6,9-10,13-15,19,23-24H,2,4,7-8,11-12,16H2,1H3
• InChIKey: VHQAJFNLPQULSV-UHFFFAOYSA-N
• SMILES: CCOC(=O)C1=CC(=C(C=C1)NC2CCCCC2)NCC3=CC=CC=C3

SRS11-92 (Cat No.: I045555) is a selective small-molecule allosteric agonist of the metabotropic glutamate receptor 2 (mGluR2), developed as a pharmacological probe for neuroscience research. By enhancing mGluR2 signaling, it modulates glutamatergic neurotransmission, contributing to the regulation of anxiety, stress responses, and cognition. SRS11-92 has been investigated for its potential therapeutic relevance in schizophrenia, depression, and other neuropsychiatric disorders. With high potency and receptor selectivity, it provides a valuable tool for exploring mGluR2 pharmacology, glutamate signaling, and novel central nervous system therapies.

Reference

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[2]. Cotticelli MG, et al. Ferroptosis as a Novel Therapeutic Target for Friedreich’s Ataxia. J Pharmacol Exp Ther. 2019;369(1):47-54.
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