(S,R,S)-AHPC-PEG2-NH2 dihydrochloride

• CAT Number: I015587
• CAS Number: 2341796-76-5
• Molecular Formula: C28H43Cl2N5O6S
• Molecular Weight: 648.64
• Purity: ≥95%
• Synonyms: (2S,4R)-1-[(2S)-2-[[2-[2-(2-aminoethoxy)ethoxy]acetyl]amino]-3,3-dimethylbutanoyl]-4-hydroxy-N-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]pyrrolidine-2-carboxamide;dihydrochloride
• InChI: InChI=1S/C28H41N5O6S.2ClH/c1-18-24(40-17-31-18)20-7-5-19(6-8-20)14-30-26(36)22-13-21(34)15-33(22)27(37)25(28(2,3)4)32-23(35)16-39-12-11-38-10-9-29;;/h5-8,17,21-22,25,34H,9-16,29H2,1-4H3,(H,30,36)(H,32,35);2*1H/t21-,22+,25-;;/m1../s1
• InChIKey: JHDIGXLPWYVAKX-OTCWRJAQSA-N
• SMILES: CC1=C(SC=N1)C2=CC=C(C=C2)CNC(=O)[C@@H]3C[C@H](CN3C(=O)[C@H](C(C)(C)C)NC(=O)COCCOCCN)O.Cl.Cl

(S,R,S)-AHPC-PEG2-NH2 dihydrochloride（Cat No.:I015587）is a bifunctional chemical building block used in PROTAC (proteolysis-targeting chimera) research. The AHPC moiety binds the von Hippel–Lindau (VHL) E3 ubiquitin ligase, enabling targeted protein degradation, while the PEG2 linker provides flexibility and solubility for conjugation to a ligand of interest. The terminal amine group allows further functionalization in synthetic chemistry. Supplied as a dihydrochloride salt, it ensures stability and handling convenience. This compound is widely applied in medicinal chemistry and chemical biology for designing novel degraders to explore therapeutic protein knockdown strategies.