SB225002

• CAT Number: I002369
• CAS Number: 182498-32-4
• Molecular Formula: C13H10BrN3O4
• Molecular Weight: 352.1
• Purity: ≥95%
• Target: CXCR2 inhibitor
• Solubility: 10 mM in DMSO
• Storage: -20°C
• IC50: 22 nM(inhibition of 125I-IL-8 binding to CXCR2) [1]
• InChI: InChI=1S/C13H10BrN3O4/c14-9-3-1-2-4-10(9)15-13(19)16-11-6-5-8(17(20)21)7-12(11)18/h1-7,18H,(H2,15,16,19)
• InChIKey: MQBZVUNNWUIPMK-UHFFFAOYSA-N
• SMILES: OC1=CC([N+]([O-])=O)=CC=C1NC(NC2=C(Br)C=CC=C2)=O

SB225002 (CAT: I002369) is a potent and selective non-peptide inhibitor of CXCR2, a chemokine receptor. Chemokine receptors, including CXCR2, play a crucial role in mediating immune cell migration and activation. By inhibiting CXCR2, SB225002 hinders the signaling pathways that regulate immune cell movement and recruitment to inflammatory sites. This inhibition holds promise for modulating immune responses and offers potential therapeutic applications in conditions involving excessive inflammation, such as autoimmune diseases or inflammatory disorders.

Reference

1:SB225002 Induces Cell Death and Cell Cycle Arrest in Acute Lymphoblastic Leukemia Cells through the Activation of GLIPR1. de Vasconcellos JF, Laranjeira AB, Leal PC, Bhasin MK, Zenatti PP, Nunes RJ, Yunes RA, Nowill AE, Libermann TA, Zerbini LF, Yunes JA.PLoS One. 2015 Aug 24;10(8):e0134783. doi: 10.1371/journal.pone.0134783. eCollection 2015. PMID: 26302043 Free PMC Article2:Molecular mechanisms of the antitumor activity of SB225002: a novel microtubule inhibitor. Goda AE, Koyama M, Sowa Y, Elokely KM, Yoshida T, Kim BY, Sakai T.Biochem Pharmacol. 2013 Jun 15;85(12):1741-52. doi: 10.1016/j.bcp.2013.04.011. Epub 2013 Apr 20. PMID: 23611835 3:SB225002 promotes mitotic catastrophe in chemo-sensitive and -resistant ovarian cancer cells independent of p53 status in vitro. Du M, Qiu Q, Gruslin A, Gordon J, He M, Chan CC, Li D, Tsang BK.PLoS One. 2013;8(1):e54572. doi: 10.1371/journal.pone.0054572. Epub 2013 Jan 24. PMID: 23359652 Free PMC Article4:[Selective non-peptide CXCR2 antagonist SB225002 inhibits choroidal neovascularization in rat model]. Qu Y, Zhou F, Xu XY.Zhonghua Yan Ke Za Zhi. 2009 Aug;45(8):742-5. Chinese. PMID: 20021889 5:The effects of the selective and non-peptide CXCR2 receptor antagonist SB225002 on acute and long-lasting models of nociception in mice. Manjavachi MN, Quintão NL, Campos MM, Deschamps IK, Yunes RA, Nunes RJ, Leal PC, Calixto JB.Eur J Pain. 2010 Jan;14(1):23-31. doi: 10.1016/j.ejpain.2009.01.007. Epub 2009 Mar 4. PMID: 19264522 6:The selective nonpeptide CXCR2 antagonist SB225002 ameliorates acute experimental colitis in mice. Bento AF, Leite DF, Claudino RF, Hara DB, Leal PC, Calixto JB.J Leukoc Biol. 2008 Oct;84(4):1213-21. doi: 10.1189/jlb.0408231. Epub 2008 Jul 24. PMID: 18653784