For research use only. Not for therapeutic Use.
(S,R,S)-AHPC-C5-COOH（Cat No.:I016162）is a synthetic ligand derivative designed for targeted protein degradation and PROTAC research. It is based on the AHPC (aryl hydroxyproline-containing) scaffold, which binds the Von Hippel–Lindau (VHL) E3 ubiquitin ligase complex. The compound contains a C5 linker terminating with a carboxylic acid, enabling further conjugation to ligands for proteins of interest. The stereospecific (S,R,S) configuration ensures high-affinity binding and functional activity. This reagent is valuable for developing heterobifunctional degraders, chemical biology studies, and therapeutic exploration in cancer, immunology, and neurodegenerative disease research.
| CAS Number | 2267282-19-7 |
| Synonyms | 7-[[(2S)-1-[(2S,4R)-4-hydroxy-2-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methylcarbamoyl]pyrrolidin-1-yl]-3,3-dimethyl-1-oxobutan-2-yl]amino]heptanoic acid |
| Molecular Formula | C29H42N4O5S |
| Purity | ≥95% |
| IUPAC Name | 7-[[(2S)-1-[(2S,4R)-4-hydroxy-2-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methylcarbamoyl]pyrrolidin-1-yl]-3,3-dimethyl-1-oxobutan-2-yl]amino]heptanoic acid |
| InChI | InChI=1S/C29H42N4O5S/c1-19-25(39-18-32-19)21-12-10-20(11-13-21)16-31-27(37)23-15-22(34)17-33(23)28(38)26(29(2,3)4)30-14-8-6-5-7-9-24(35)36/h10-13,18,22-23,26,30,34H,5-9,14-17H2,1-4H3,(H,31,37)(H,35,36)/t22-,23+,26-/m1/s1 |
| InChIKey | SCVBFBWIXTXYQE-MVERNJQCSA-N |
| SMILES | CC1=C(SC=N1)C2=CC=C(C=C2)CNC(=O)[C@@H]3C[C@H](CN3C(=O)[C@H](C(C)(C)C)NCCCCCCC(=O)O)O |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
