SR-318

• CAT Number: I016855
• CAS Number: 2413286-32-3
• Molecular Formula: C₂₇H₃₃N₅O₂
• Molecular Weight: 459.58
• Purity: ≥95%
• IUPAC Name: 5-amino-N-[[4-(3-cyclohexylpropylcarbamoyl)phenyl]methyl]-1-phenylpyrazole-4-carboxamide
• InChI: InChI=1S/C27H33N5O2/c28-25-24(19-31-32(25)23-11-5-2-6-12-23)27(34)30-18-21-13-15-22(16-14-21)26(33)29-17-7-10-20-8-3-1-4-9-20/h2,5-6,11-16,19-20H,1,3-4,7-10,17-18,28H2,(H,29,33)(H,30,34)
• InChIKey: HXNUFFCHRIWTRZ-UHFFFAOYSA-N
• SMILES: C1CCC(CC1)CCCNC(=O)C2=CC=C(C=C2)CNC(=O)C3=C(N(N=C3)C4=CC=CC=C4)N

SR-318（Cat No.:I016855） is a powerful and specific inhibitor of p38 MAPK, targeting p38α, p38β, and p38α/β with IC50 values of 5 nM, 32 nM, and 6.11 μM, respectively. It effectively suppresses TNF-α release in whole blood, displaying an IC50 of 283 nM. This compound exhibits noteworthy anti-cancer and anti-inflammatory properties, making it a promising candidate for therapeutic applications.

Reference

[1]. Röhm S, et al. Fast Iterative Synthetic Approach toward Identification of Novel Highly Selective p38 MAP Kinase Inhibitors. J Med Chem. 2019 Dec 12;62(23):10757-10782.