Sparfloxacin

  • CAT Number: A000639
  • CAS Number: 110871-86-8
  • Molecular Formula: C19H22F2N4O3
  • Molecular Weight: 392.4
  • Purity: ≥95%
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Sparfloxacin trade names Spacin in Bangladesh, Zagam and Zagam Respipac, is a fluoroquinolone antibiotic used in the treatment of bacterial infections.

Catalog Number A000639
CAS Number 110871-86-8
Molecular Formula

C19H22F2N4O3

Purity 95%
Storage -20°C
InChI 1S/C19H22F2N4O3/c1-8-5-24(6-9(2)23-8)17-13(20)15(22)12-16(14(17)21)25(10-3-4-10)7-11(18(12)26)19(27)28/h7-10,23H,3-6,22H2,1-2H3,(H,27,28)/t8-,9+
InChIKey DZZWHBIBMUVIIW-DTORHVGOSA-N
SMILES CC1CN(CC(N1)C)C2=C(C3=C(C(=C2F)N)C(=O)C(=CN3C4CC4)C(=O)O)F
Reference

1: Kouris E, Kalogiannis S, Perdih F, Turel I, Psomas G. Cobalt(II) complexes of
sparfloxacin: Characterization, structure, antimicrobial activity and interaction
with DNA and albumins. J Inorg Biochem. 2016 Oct;163:18-27. doi:
10.1016/j.jinorgbio.2016.07.022. Epub 2016 Jul 28. PubMed PMID: 27501348.
<br>

2: Pridgeon JW, Klesius PH. Retraction notice to /Development of live attenuated
Streptococcus agalactiae as potential vaccines by selecting for resistance to
sparfloxacin/ [Vaccine 31 (2013) 2705-2712]. Vaccine. 2016 Aug 31;34(38):4642.
doi: 10.1016/j.vaccine.2016.07.043. Epub 2016 Aug 20. PubMed PMID: 27553749.

<br>
3: Garlapati R, Venigalla BS, Surakanti JR, Thumu J, Chennamaneni KC, Kalluru RS.
Comparison of the Antimicrobial Efficacy of Two Antibiotics Sparfloxacin and
Augmentin as Experimental Root Canal Irrigating Solutions against Enterococcus
faecalis – An Invitro Study. J Clin Diagn Res. 2016 Mar;10(3):ZC57-60. doi:
10.7860/JCDR/2016/17199.7470. Epub 2016 Mar 1. PubMed PMID: 27135003; PubMed
Central PMCID: PMC4843388.

<br>
4: An Z, Gao J, Harrison WT. Crystal structures of
[Mn(bdc)(Hspar)2(H2O)0.25]·2H2O containing MnO6+1 capped trigonal prisms and
[Cu(Hspar)2](bdc)·2H2O containing CuO4 squares (Hspar = sparfloxacin and bdc =
benzene-1,4-di-carboxyl-ate). Acta Crystallogr E Crystallogr Commun. 2016 Jan
1;72(Pt 1):96-101. doi: 10.1107/S205698901502424X. eCollection 2016 Jan 1. PubMed
PMID: 26870595; PubMed Central PMCID: PMC4704758.

<br>
5: Komarnicka UK, Starosta R, P&#322;otek M, de Almeida RF, Je&#380;owska-Bojczuk M, Kyzio&#322;
A. Copper(I) complexes with phosphine derived from sparfloxacin. Part II: a first
insight into the cytotoxic action mode. Dalton Trans. 2016 Mar 28;45(12):5052-63.
doi: 10.1039/c5dt04011f. PubMed PMID: 26674970.
<br>

6: Ambhore NP, Dandagi PM, Gadad AP. Formulation and comparative evaluation of
HPMC and water soluble chitosan-based sparfloxacin nanosuspension for ophthalmic
delivery. Drug Deliv Transl Res. 2016 Feb;6(1):48-56. doi:
10.1007/s13346-015-0262-y. PubMed PMID: 26545605.
<br>

7: Gupta H, Malik A, Khar RK, Ali A, Bhatnagar A, Mittal G. Physiologically
active hydrogel (in situ gel) of sparfloxacin and its evaluation for ocular
retention using gamma scintigraphy. J Pharm Bioallied Sci. 2015
Jul-Sep;7(3):195-200. doi: 10.4103/0975-7406.160015. PubMed PMID: 26229353;
PubMed Central PMCID: PMC4517321.

<br>
8: Komarnicka UK, Starosta R, Kyzio&#322; A, Je&#380;owska-Bojczuk M. Copper(i) complexes
with phosphine derived from sparfloxacin. Part I – structures, spectroscopic
properties and cytotoxicity. Dalton Trans. 2015 Jul 28;44(28):12688-99. doi:
10.1039/c5dt01146a. PubMed PMID: 26085118.

<br>
9: Liang W, Liu S, Song J, Hao C, Wang L, Li D, He Y. Highly sensitive
fluorescence biosensors for sparfloxacin detection at nanogram level based on
electron transfer mechanism of cadmium telluride quantum dots. Biotechnol Lett.
2015 May;37(5):1057-61. doi: 10.1007/s10529-015-1767-7. Epub 2015 Jan 22. PubMed
PMID: 25604522.
<br>

10: Beberok A, Wrze&#347;niok D, Otr&#281;ba M, Buszman E. Impact of sparfloxacin on
melanogenesis and antioxidant defense system in normal human melanocytes HEMa-LP
– An in vitro study. Pharmacol Rep. 2015 Feb;67(1):38-43. doi:
10.1016/j.pharep.2014.07.015. Epub 2014 Aug 10. PubMed PMID: 25560573.

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