Sp-cAMPS sodium salt

• CAT Number: I011728
• CAS Number: 142439-95-0
• Molecular Formula: C10H11N5NaO5PS
• Molecular Weight: 367.25
• Purity: ≥95%
• IUPAC Name: sodium;(4aR,6R,7R,7aS)-6-(6-aminopurin-9-yl)-2-oxido-2-sulfanylidene-4a,6,7,7a-tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-7-ol
• InChI: InChI=1S/C10H12N5O5PS.Na/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7-4(19-10)1-18-21(17,22)20-7;/h2-4,6-7,10,16H,1H2,(H,17,22)(H2,11,12,13);/q;+1/p-1/t4-,6-,7-,10-,21?;/m1./s1
• InChIKey: YTUKZYORDGLGPR-NVGWRVNNSA-M
• SMILES: C1[C@@H]2[C@H]([C@H]([C@@H](O2)N3C=NC4=C(N=CN=C43)N)O)OP(=S)(O1)[O-].[Na+]

Sp-cAMPS sodium salt（Cat No.:I011728）is a synthetic, cell-permeable analog of cyclic adenosine monophosphate (cAMP) that acts as a potent activator of cAMP-dependent protein kinase (PKA). By binding to the regulatory subunit of PKA, it promotes dissociation and activation of catalytic subunits, thereby stimulating downstream phosphorylation events. Unlike natural cAMP, Sp-cAMPS is resistant to hydrolysis by phosphodiesterases, providing sustained signaling effects. The sodium salt form enhances solubility and stability. Sp-cAMPS sodium salt is widely used in research to study cAMP/PKA-mediated pathways in metabolism, transcription, neurobiology, and cardiovascular function.