(S)-Ceralasertib

• CAT Number: I018275
• CAS Number: 1352226-87-9
• Molecular Formula: C₂₀H₂₄N₆O₂S
• Molecular Weight: 412.51
• Purity: ≥95%
• Storage: Store at -20°C
• IUPAC Name: imino-methyl-[1-[6-[(3R)-3-methylmorpholin-4-yl]-2-(1H-pyrrolo[2,3-b]pyridin-4-yl)pyrimidin-4-yl]cyclopropyl]-oxo-λ6-sulfane
• InChI: InChI=1S/C20H24N6O2S/c1-13-12-28-10-9-26(13)17-11-16(20(5-6-20)29(2,21)27)24-19(25-17)15-4-8-23-18-14(15)3-7-22-18/h3-4,7-8,11,13,21H,5-6,9-10,12H2,1-2H3,(H,22,23)/t13-,29+/m1/s1
• InChIKey: OHUHVTCQTUDPIJ-MUWSIPGASA-N
• SMILES: CC1COCCN1C2=NC(=NC(=C2)C3(CC3)S(=N)(=O)C)C4=C5C=CNC5=NC=C4

(S)-Ceralasertib (Cat No.:I018275) is a small molecule inhibitor of the ATR protein kinase, which plays a key role in the DNA damage response and cell cycle regulation. As a potential anticancer agent, (S)-Ceralasertib has shown promise in preclinical studies and is currently being evaluated in clinical trials for the treatment of various types of cancer. The drug selectively targets cancer cells while sparing normal cells, and is believed to enhance the activity of DNA-damaging agents used in cancer therapy.

Reference

[1]. By Foote, et al. Morpholinopyrimidines as ATR kinase inhibitors and their preparation, pharmaceutical compositions and use in the treatment of cancer. PCT Int. Appl. (2011), WO 2011154737 A1 20111215.[2]. Foote KM, et al. Discovery and Characterization of AZD6738, a Potent Inhibitor of Ataxia Telangiectasia Mutatedand Rad3 Related (ATR) Kinase with Application as an Anticancer Agent. J Med Chem. 2018 Nov 21;61(22):9889-9907.