SP-2509

• CAT Number: I001637
• CAS Number: 1423715-09-6
• Molecular Formula: C₁₉H₂₀ClN₃O₅S
• Molecular Weight: 437.9
• Purity: ≥95%
• Target: Histone Demethylases
• Solubility: DMSO: ≥ 35 mg/mL
• Storage: Store at -20°C
• IC50: 13 nM [1]
• IUPAC Name: N-[(E)-1-(5-chloro-2-hydroxyphenyl)ethylideneamino]-3-morpholin-4-ylsulfonylbenzamide
• InChI: InChI=1S/C19H20ClN3O5S/c1-13(17-12-15(20)5-6-18(17)24)21-22-19(25)14-3-2-4-16(11-14)29(26,27)23-7-9-28-10-8-23/h2-6,11-12,21H,7-10H2,1H3,(H,22,25)/b17-13-
• InChIKey: ZVVCYRYDHNYAPV-LGMDPLHJSA-N
• SMILES: CC(=C1C=C(C=CC1=O)Cl)NNC(=O)C2=CC(=CC=C2)S(=O)(=O)N3CCOCC3

SP2509 (Cat No.:I001637) is a potent and selective inhibitor of histone demethylase LSD1, with an IC50 value of 13 nM. It does not show activity against other enzymes like MAO-A, MAO-B, lactate dehydrogenase, and glucose oxidase. The compound is known to induce apoptosis and promote autophagy in various cell types.

Reference

[1]. Fiskus W, et al. Highly effective combination of LSD1 (KDM1A) antagonist and pan-histone deacetylase inhibitor against human AML cells. Leukemia. 2014 Nov;28(11):2155-64.