Solamargine

• CAT Number: I002566
• CAS Number: 20311-51-7
• Molecular Formula: C45H73NO15
• Molecular Weight: 868.06
• Purity: ≥95%
• Target: Anticancer natural compound
• Solubility: DMSO: ≥ 8.8 mg/mL
• Storage: Store at -20°C

Solamargine (CAT: I002566) is a naturally occurring steroidal glycoalkaloid found in plants of the Solanaceae family, such as Solanum nigrum and Solanum melongena. It possesses various biological activities, including anticancer, antifungal, and antiviral properties. Solamargine has been extensively studied for its potential as an anticancer agent due to its ability to induce apoptosis, inhibit cell proliferation, and suppress tumor growth. It exerts its anticancer effects by targeting multiple signaling pathways involved in cell survival, proliferation, and metastasis.

Reference

[1]. Sani IK, et al. Solamargine inhibits migration and invasion of human hepatocellular carcinoma cells through down-regulation of matrix metalloproteinases 2 and 9 expression and activity. Toxicol In Vitro. 2015 Mar 27;29(5):893-900.
[2]. Zhou Y, et al. Targeting signal transducer and activator of transcription 3 contributes to the solamargine-inhibited growth and -induced apoptosis of human lung cancer cells. Tumour Biol. 2014 Aug;35(8):8169-78.
[3]. Ding X, et al. Induction of apoptosis in human hepatoma SMMC-7721 cells by solamargine from Solanum nigrum L. J Ethnopharmacol. 2012 Jan 31;139(2):599-604.