Sodium orthovanadate, Activated

• CAT Number: A000481
• CAS Number: 13721-39-6
• Molecular Formula: Na3VO4
• Molecular Weight: 183.907
• Purity: ≥95%
• Target: ATPase
• Solubility: Limited solubility
• Storage: 3 years -20C powder
• IUPAC Name: trisodium;trioxido(oxo)vanadium
• InChI: InChI=1S/3Na.4O.V/q3*+1;;3*-1
• InChIKey: IHIXIJGXTJIKRB-UHFFFAOYSA-N
• SMILES: [O-][V](=O)([O-])[O-].[Na+].[Na+].[Na+]

Sodium orthovanadate is an alkaline phosphatase and (Na,K)-ATPase inhibitor with IC50 of 10 μM.In transient forebrain ischemia, Sodium orthovanadate rescues cells from delayed neuronal death in the hippocampal CA1 region. The neuroprotective effects of Sodium orthovanadate and IGF-1 are associated with preventing decreased Akt-Ser-473 phosphorylation in the CA1 region observed immediately after reperfusion. Akt is moderately activated in the cell bodies and dendrites of pyramidal neurons after orthovanadate treatment. The Sodium orthovanadate treatment also prevents the decrease in phosphorylation of mitogen-activated protein kinase (MAPK).In a rat model of myocardial ischemic infarction, sodium orthovanadate rescues cells from ischemia/reperfusion injuries. Post-treatment with Sodium orthovanadate reduces infarct size in a dose-dependent manner.