Sodium Dichloroacetate

• CAT Number: I009546
• CAS Number: 2156-56-1
• Molecular Formula: C2HCl2NaO2
• Molecular Weight: 150.918
• Purity: ≥95%
• Target: Pyruvate dehydrogenase inhibitor
• Solubility: Soluble in water.
• Storage: 0 - 4 °C for short term, or -20 °C for long term
• IUPAC Name: sodium;2,2-dichloroacetate
• InChI: InChI=1S/C2H2Cl2O2.Na/c3-1(4)2(5)6;/h1H,(H,5,6);/q;+1/p-1
• InChIKey: LUPNKHXLFSSUGS-UHFFFAOYSA-M
• SMILES: C(C(=O)[O-])(Cl)Cl.[Na+]

Sodium Dichloroacetate (CAT: I009546), also known as CPC-211; DCA; X-11S, acts as an inhibitor of pyruvate dehydrogenase kinase (PDK), which leads to the reactivation of pyruvate dehydrogenase (PDH) enzyme and promotes the oxidation of glucose in the mitochondria. This metabolic shift towards oxidative metabolism has been suggested to inhibit the growth of cancer cells and restore their susceptibility to apoptosis. DCA has shown promising anticancer effects in preclinical studies and is currently being investigated in clinical trials for various types of cancer. In addition, DCA has been explored for its potential in treating metabolic disorders, such as mitochondrial diseases and diabetes.

Reference

1:Crosstalk among proteome, acetylome and succinylome in colon cancer HCT116 cell treated with sodium dichloroacetate. Zhu D, Hou L, Hu B, Zhao H, Sun J, Wang J, Meng X.Sci Rep. 2016 Nov 22;6:37478. doi: 10.1038/srep37478. PMID: 27874079 Free PMC Article
2:Long-term stabilization of stage 4 colon cancer using sodium dichloroacetate therapy. Khan A, Andrews D, Blackburn AC.World J Clin Cases. 2016 Oct 16;4(10):336-343. PMID: 27803917 Free PMC Article
3:Effectiveness of sodium dichloroacetate against glioma C6 depends on administration schedule and dosage. Fedorchuk AG, Pyaskovskaya ON, Gorbik GV, Prokhorova IV, Kolesnik DL, Solyanik GI.Exp Oncol. 2016 Jun;38(2):80-3. PMID: 27356574
4:Metformin combined with sodium dichloroacetate promotes B leukemic cell death by suppressing anti-apoptotic protein Mcl-1. Voltan R, Rimondi E, Melloni E, Gilli P, Bertolasi V, Casciano F, Rigolin GM, Zauli G, Secchiero P.Oncotarget. 2016 Apr 5;7(14):18965-77. doi: 10.18632/oncotarget.7879. PMID: 26959881 Free PMC Article
5:Functional and dynamic state of inner mitochondrial membrane of sarcoma 37 in mice under administration of sodium dichloroacetate. Khyzhnyak SV, Sorokina LV, Stepanova LI, Kaplia AA.Ukr Biochem J. 2014 Nov-Dec;86(6):106-18. PMID: 25816611
6:The anti-leukemic activity of sodium dichloroacetate in p53mutated/null cells is mediated by a p53-independent ILF3/p21 pathway. Agnoletto C, Brunelli L, Melloni E, Pastorelli R, Casciano F, Rimondi E, Rigolin GM, Cuneo A, Secchiero P, Zauli G.Oncotarget. 2015 Feb 10;6(4):2385-96. PMID: 25544776 Free PMC Article
7:Sodium dichloroacetate exhibits anti-leukemic activity in B-chronic lymphocytic leukemia (B-CLL) and synergizes with the p53 activator Nutlin-3. Agnoletto C, Melloni E, Casciano F, Rigolin GM, Rimondi E, Celeghini C, Brunelli L, Cuneo A, Secchiero P, Zauli G.Oncotarget. 2014 Jun 30;5(12):4347-60. PMID: 24962518 Free PMC Article
8:Case report: Sodium dichloroacetate (DCA) inhibition of the /Warburg Effect/ in a human cancer patient: complete response in non-Hodgkin/'s lymphoma after disease progression with rituximab-CHOP. Strum SB, Adalsteinsson O, Black RR, Segal D, Peress NL, Waldenfels J.J Bioenerg Biomembr. 2013 Jun;45(3):307-15. doi: 10.1007/s10863-012-9496-2. Epub 2012 Dec 20. Erratum in: J Bioenerg Biomembr. 2013 Jun;45(3):317. PMID: 23263938
9:The influence of sodium dichloroacetate on the oxidative processes in sarcoma 37. Sorokina LV, Pyatchanina TV, Didenko GV, Kaplia AA, Khyzhnyak SV.Exp Oncol. 2011 Dec;33(4):216-21. PMID: 22217710
10:Sodium dichloroacetate (DCA) reduces apoptosis in colorectal tumor hypoxia. Shahrzad S, Lacombe K, Adamcic U, Minhas K, Coomber BL.Cancer Lett. 2010 Nov 1;297(1):75-83. doi: 10.1016/j.canlet.2010.04.027. Epub 2010 May 26. PMID: 20537792