SN-38

• CAT Number: I005211
• CAS Number: 86639-52-3
• Molecular Formula: C22H20N2O5
• Molecular Weight: 392.40
• Purity: ≥95%
• Synonyms: 7-Ethyl-10-Hydroxycamptothecin;7-ethyl-10-hydroxy-20(S)-Camptothecin;NK 012
• Target: Cell Cycle/DNA Damage
• Solubility: DMSO: ≥ 40 mg/mL
• Storage: -20℃
• IUPAC Name: (19S)-10,19-diethyl-7,19-dihydroxy-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaene-14,18-dione
• InChI: InChI=1S/C22H20N2O5/c1-3-12-13-7-11(25)5-6-17(13)23-19-14(12)9-24-18(19)8-16-15(20(24)26)10-29-21(27)22(16,28)4-2/h5-8,25,28H,3-4,9-10H2,1-2H3/t22-/m0/s1
• InChIKey: FJHBVJOVLFPMQE-QFIPXVFZSA-N
• SMILES: CCC1=C2CN3C(=CC4=C(C3=O)COC(=O)[C@@]4(CC)O)C2=NC5=C1C=C(C=C5)O

SN-38（Cat No.:I005211）is the active metabolite of irinotecan, a chemotherapeutic agent used to treat cancers, particularly colorectal cancer. It exerts its anticancer effects by inhibiting topoisomerase I, an enzyme crucial for DNA replication and transcription. By stabilizing the enzyme-DNA complex, SN-38 induces DNA strand breaks, leading to cell death, particularly in rapidly dividing cancer cells. Though more potent than irinotecan, SN-38’s clinical use is limited due to poor solubility and rapid clearance. Efforts to enhance its therapeutic profile involve drug delivery systems and prodrug formulations to improve stability and bioavailability.