SLF TFA

For research use only. Not for therapeutic Use.

  • CAT Number: I045579
  • CAS Number: 2378802-47-0
  • Molecular Formula: C32H41F3N2O8
  • Molecular Weight: 638.67
  • Purity: ≥95%
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SLF TFA (Cat No.: I045579) is a high-affinity ligand for FK506-binding proteins (FKBPs), commonly used in chemical biology and protein engineering. As a derivative of the immunophilin-binding ligand FK506, SLF retains strong binding activity without immunosuppressive effects. It is widely applied in the study of protein–protein interactions, targeted protein degradation, and chemical-induced dimerization systems. The TFA salt form enhances stability and handling, making SLF TFA a versatile research tool for probing FKBP-mediated signaling and synthetic biology applications.


CAS Number 2378802-47-0
Synonyms

[(1R)-1-(3-aminophenyl)-3-(3,4-dimethoxyphenyl)propyl] (2S)-1-(3,3-dimethyl-2-oxopentanoyl)piperidine-2-carboxylate;2,2,2-trifluoroacetic acid

Molecular Formula C32H41F3N2O8
Purity ≥95%
InChI InChI=1S/C30H40N2O6.C2HF3O2/c1-6-30(2,3)27(33)28(34)32-17-8-7-12-23(32)29(35)38-24(21-10-9-11-22(31)19-21)15-13-20-14-16-25(36-4)26(18-20)37-5;3-2(4,5)1(6)7/h9-11,14,16,18-19,23-24H,6-8,12-13,15,17,31H2,1-5H3;(H,6,7)/t23-,24+;/m0./s1
InChIKey HKRBJXCFMLSYKV-KZDWWKKTSA-N
SMILES CCC(C)(C)C(=O)C(=O)N1CCCCC1C(=O)OC(CCC2=CC(=C(C=C2)OC)OC)C3=CC(=CC=C3)N.C(=O)(C(F)(F)F)O
Reference

[1]. Kolos JM, et al. FKBP Ligands-Where We Are and Where to Go? Front Pharmacol. 2018 Dec 5;9:1425.
[Content Brief]

[2]. Wu X, et al. Creating diverse target-binding surfaces on FKBP12: synthesis and evaluation of a rapamycin analogue library. ACS Comb Sci. 2011 Sep 12;13(5):486-95.
[Content Brief]

[3]. Zhang X, et al. Electrophilic PROTACs that degrade nuclear proteins by engaging DCAF16. Nat Chem Biol. 2019 Jul;15(7):737-746.
[Content Brief]

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