For research use only. Not for therapeutic Use.
SLC13A5-IN-1(CAT: I045992) is a highly selective sodium–citrate co-transporter (SLC13A5) inhibitor, identified from patent WO2018104220A1 (Compound I-5). It potently blocks citrate uptake with IC₅₀ = 0.022 μM in HepG2 cells, which endogenously express hSLC13A5, and IC₅₀ = 0.056 μM in recombinant hSLC13A5 assays. The inhibition is specific, as demonstrated by weak activity in the GlyT2/³H-glycine uptake assay (IC₅₀ = 100 μM). By regulating intracellular citrate transport, SLC13A5-IN-1 offers a powerful tool for studying citrate metabolism, energy homeostasis, and lipid biosynthesis. It holds strong therapeutic potential for metabolic and cardiovascular diseases, where citrate signaling plays a key role.
| CAS Number | 2227548-95-8 |
| Synonyms | N-[(4-chlorophenyl)methyl]-1-(3,5-dichlorophenyl)sulfonylpiperidine-4-carboxamide |
| Molecular Formula | C19H19Cl3N2O3S |
| Purity | ≥95% |
| IUPAC Name | N-[(4-chlorophenyl)methyl]-1-(3,5-dichlorophenyl)sulfonylpiperidine-4-carboxamide |
| InChI | InChI=1S/C19H19Cl3N2O3S/c20-15-3-1-13(2-4-15)12-23-19(25)14-5-7-24(8-6-14)28(26,27)18-10-16(21)9-17(22)11-18/h1-4,9-11,14H,5-8,12H2,(H,23,25) |
| InChIKey | NPEIWANTVUZMJV-UHFFFAOYSA-N |
| SMILES | C1CN(CCC1C(=O)NCC2=CC=C(C=C2)Cl)S(=O)(=O)C3=CC(=CC(=C3)Cl)Cl |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
