SKF-83566（Cat No.:I045787）is a potent and selective antagonist of dopamine D1-like receptors (D1 and D5), widely used as a pharmacological tool in neuroscience research. By blocking D1 receptor–mediated signaling, it reduces cAMP accumulation and modulates dopaminergic pathways involved in motor control, cognition, and reward processing. SKF-83566 has been applied in studies of Parkinson’s disease, schizophrenia, addiction, and learning and memory, providing insights into dopamine receptor function. Its high receptor selectivity makes it valuable for dissecting D1 receptor–specific mechanisms and exploring therapeutic strategies targeting dopaminergic dysregulation in neuropsychiatric disorders.