Pixantrone - CAS 144510-96-3

Pixantrone (BBR 2778) is an experimental antineoplastic drug.
Target: Others
Pixantrone is an experimental antineoplastic (anti-cancer) drug, an analogue of mitoxantrone with fewer toxic effects on cardiac tissue, It acts as a topoisomerase II poison and intercalating agent. Pixantrone may be useful in patients pretreated with anthracyclines [1]. An in vitro crosslinking assay demonstrated that Pixantrone is efficiently activated by formaldehyde to generate covalent drug-DNA adducts capable of stabilizing double-stranded DNA in denaturing conditions. Pixantrone-DNA adduct formation is both concentration and time dependent and the reaction exhibits an absolute requirement for formaldehyde. Pixantrone exhibited a 10- to 100-fold greater propensity to generate adducts at equimolar formaldehyde and drug concentrations. Pixantrone-DNA adducts are thermally and temporally labile, yet they exhibit a greater thermal midpoint temperature and an extended half-life at 37 degrees C when compared to mitoxantrone-DNA adducts [2].

Catalog Number: I001709

CAS Number: 144510-96-3

PubChem Substance ID:355039525

Molecular Formula: C17H19N5O2

Molecular Weight:325.37

Purity: ≥95%

* For research use only. Not for human or veterinary use.


Molecular Formula: C17H19N5O2
Molecular Weight325.37
Solubility10 mM in DMSO