<p style=/line-height:25px/>Pixantrone (BBR 2778) is an experimental antineoplastic drug.<br>Target: Others<br>Pixantrone is an experimental antineoplastic (anti-cancer) drug, an analogue of mitoxantrone with fewer toxic effects on cardiac tissue, It acts as a topoisomerase II poison and intercalating agent. Pixantrone may be useful in patients pretreated with anthracyclines [1]. An in vitro crosslinking assay demonstrated that Pixantrone is efficiently activated by formaldehyde to generate covalent drug-DNA adducts capable of stabilizing double-stranded DNA in denaturing conditions. Pixantrone-DNA adduct formation is both concentration and time dependent and the reaction exhibits an absolute requirement for formaldehyde. Pixantrone exhibited a 10- to 100-fold greater propensity to generate adducts at equimolar formaldehyde and drug concentrations. Pixantrone-DNA adducts are thermally and temporally labile, yet they exhibit a greater thermal midpoint temperature and an extended half-life at 37 degrees C when compared to mitoxantrone-DNA adducts [2].<br></p>
Catalog Number | I001709 |
CAS Number | 144510-96-3 |
Molecular Formula | C17H19N5O2 |
Purity | ≥95% |
Target | Others |
Solubility | 10 mM in DMSO |
Storage | -20°C |
Reference | <p style=/line-height:25px/> <br>[2]. Evison, B.J., et al., Pixantrone can be activated by formaldehyde to generate a potent DNA adduct forming agent. Nucleic Acids Res, 2007. 35(11): p. 3581-9. </p> |