• CAT Number: I001709
  • CAS Number: 144510-96-3
  • Molecular Formula: C17H19N5O2
  • Molecular Weight: 325.37
  • Purity: ≥95%
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<p style=/line-height:25px/>Pixantrone (BBR 2778) is an experimental antineoplastic drug.<br>Target: Others<br>Pixantrone is an experimental antineoplastic (anti-cancer) drug, an analogue of mitoxantrone with fewer toxic effects on cardiac tissue, It acts as a topoisomerase II poison and intercalating agent. Pixantrone may be useful in patients pretreated with anthracyclines [1]. An in vitro crosslinking assay demonstrated that Pixantrone is efficiently activated by formaldehyde to generate covalent drug-DNA adducts capable of stabilizing double-stranded DNA in denaturing conditions. Pixantrone-DNA adduct formation is both concentration and time dependent and the reaction exhibits an absolute requirement for formaldehyde. Pixantrone exhibited a 10- to 100-fold greater propensity to generate adducts at equimolar formaldehyde and drug concentrations. Pixantrone-DNA adducts are thermally and temporally labile, yet they exhibit a greater thermal midpoint temperature and an extended half-life at 37 degrees C when compared to mitoxantrone-DNA adducts [2].<br></p>

Catalog Number I001709
CAS Number 144510-96-3
Molecular Formula


Purity 95%
Target Others
Solubility 10 mM in DMSO
Storage -20°C

<p style=/line-height:25px/>
<br>[1]. Cavalletti, E., et al., Pixantrone (BBR 2778) has reduced cardiotoxic potential in mice pretreated with doxorubicin: comparative studies against doxorubicin and mitoxantrone. Invest New Drugs, 2007. 25(3): p. 187-95.

<br>[2]. Evison, B.J., et al., Pixantrone can be activated by formaldehyde to generate a potent DNA adduct forming agent. Nucleic Acids Res, 2007. 35(11): p. 3581-9.


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