For research use only. Not for therapeutic Use.
SJF620(CAT: I016893) is a potent, rationally designed PROTAC (proteolysis-targeting chimera) that recruits Cereblon (CRBN) via a lenalidomide analog to induce targeted degradation of Bruton’s tyrosine kinase (BTK). In cellular assays, SJF620 demonstrates robust BTK degradation with a DC₅₀ of 7.9 nM in the Burkitt lymphoma cell line NAMALWA. Compared to earlier BTK degraders such as MT802, SJF620 displays a superior pharmacokinetic profile in mice, with a half-life of 1.64 hours at 1 mg/kg (i.v.). With its high potency, selectivity, and favorable PK, SJF620 is a valuable tool for cancer research and BTK-targeted therapeutic development.
| CAS Number | 2376187-16-3 |
| Synonyms | 3-[6-[2-[2-[2-[4-[4-amino-3-(4-phenoxyphenyl)pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl]ethoxy]ethoxy]ethoxy]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione |
| Molecular Formula | C41H44N8O7 |
| Purity | ≥95% |
| IUPAC Name | 3-[6-[2-[2-[2-[4-[4-amino-3-(4-phenoxyphenyl)pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl]ethoxy]ethoxy]ethoxy]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione |
| InChI | InChI=1S/C41H44N8O7/c42-38-36-37(27-6-8-31(9-7-27)56-30-4-2-1-3-5-30)46-49(39(36)44-26-43-38)29-14-16-47(17-15-29)18-19-53-20-21-54-22-23-55-32-10-11-33-28(24-32)25-48(41(33)52)34-12-13-35(50)45-40(34)51/h1-11,24,26,29,34H,12-23,25H2,(H2,42,43,44)(H,45,50,51) |
| InChIKey | UJJYPBWMGIPXOE-UHFFFAOYSA-N |
| SMILES | C1CC(=O)NC(=O)C1N2CC3=C(C2=O)C=CC(=C3)OCCOCCOCCN4CCC(CC4)N5C6=NC=NC(=C6C(=N5)C7=CC=C(C=C7)OC8=CC=CC=C8)N |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
