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SJ-172550

SJ-172550

  • CAT Number: I003540
  • CAS Number: 431979-47-4
  • Molecular Formula: C22H21ClN2O5
  • Molecular Weight: 428.9
  • Purity: ≥95%
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<p style=/line-height:25px/>SJ-172550 is the first MDMX inhibitor with EC50 of 0.84 uM; binds reversibly to MDMX and effectively kills retinoblastoma cells in which the expression of MDMX is amplified.<br>IC50 value: 0.84 uM(EC50) [1]<br>Target: MDMX inhibitor<br>in vitro: Unlike SJ-134433 and SJ-044557, SJ-172550 was stable in solution and did not modify the MDMX protein by covalent binding in our FP assay buffer. MDMX-p53 interaction was at least partially inhibited by SJ-172550, despite its relatively low cell permeability [1]. SJ-172550 acts through a complicated mechanism in which the compound forms a covalent but reversible complex with MDMX and locks MDMX into a conformation that is unable to bind p53 [2].</p>

Catalog Number I003540
CAS Number 431979-47-4
Molecular Formula

C22H21ClN2O5

Purity 95%
Target p53
Solubility 10 mM in DMSO
Storage Store at 4°C
IC50 0.84 uM(EC50) [1]
InChIKey RKKFQJXGAQWHBZ-YVLHZVERSA-N
Reference

<p style=/line-height:25px/>
<br>[1]. Reed D, et al. Identification and characterization of the first small molecule inhibitor of MDMX. J Biol Chem. 2010 Apr 2;285(14):10786-96.
<br>[2]. Bista M, et al. On the mechanism of action of SJ-172550 in inhibiting the interaction of MDM4 and p53. PLoS One. 2012;7(6):e37518.
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