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sitaxsentan

sitaxsentan

  • CAT Number: I002384
  • CAS Number: 184036-34-8
  • Molecular Formula: C18H15ClN2O6S2
  • Molecular Weight: 454.9
  • Purity: ≥95%
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<p style=/line-height:25px/>Sitaxsentan (IPI 1040; TBC 11251) is a selective endothelin A (ETA) receptor antagonist. Antihypertensive. Sitaxsentan is used in treatment of chronic heart failure.<br>IC50 value:<br>Target: ETA receptor</p>

Catalog Number I002384
CAS Number 184036-34-8
Synonyms

N-(4-chloro-3-methylisoxazol-5-yl)-2-(2-(6-methylbenzo[d][1,3]dioxol-5-yl)acetyl)thiophene-3-sulfonamide

Molecular Formula

C18H15ClN2O6S2

Purity 95%
Target Endothelin Receptor
Solubility 10 mM in DMSO
Storage Store at -20°C
Reference

<p style=/line-height:25px/>
<br>[1]. Kaehler, et al. Successful treatment of portopulmonary hypertension with the selective endothelin receptor antagonist Sitaxentan. Wien Klin Wochenschr. 2011 Apr;123(7-8):248-52. Epub 2011 Mar 31.

<br>[2]. Chin M, Levy RD, Yoshida EM, Byrne MF.Sitaxsentan-induced acute severe hepatitis treated with glucocorticoid therapy.Can Respir J. 2012 Jan-Feb;19(1):e1-2.

<br>[3]. Sandoval J, et al. STRIDE-4 investigators.Safety and efficacy of sitaxsentan 50 and 100 mg in patients with pulmonary arterial hypertension.Pulm Pharmacol Ther. 2012 Feb;25(1):33-9. Epub 2011 Nov 2.

<br>[4]. Safdar Z. Effect of transition from sitaxsentan to ambrisentan in pulmonary arterial hypertension.Vasc Health Risk Manag. 2011;7:119-24. Epub 2011 Mar 2.

<br>[5]. Rondelet B, et al. Sildenafil added to sitaxsentan in overcirculation-induced pulmonary arterial hypertension.Am J Physiol Heart Circ Physiol. 2010 Oct;299(4):H1118-23. Epub 2010 Aug 6.

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