Sisunatovir HCl

• CAT Number: I036317
• CAS Number: 1903763-83-6
• Molecular Formula: C23H23ClF4N4O
• Molecular Weight: 482.91
• Purity: 98%
• Solubility: Soluble in DMSO
• Storage: Store at -20°C
• IUPAC Name: 1'-[[5-(aminomethyl)-1-(4,4,4-trifluorobutyl)benzimidazol-2-yl]methyl]-6'-fluorospiro[cyclopropane-1,3'-indole]-2'-one;hydrochloride
• InChI: InChI=1S/C23H22F4N4O.ClH/c24-15-3-4-16-19(11-15)31(21(32)22(16)7-8-22)13-20-29-17-10-14(12-28)2-5-18(17)30(20)9-1-6-23(25,26)27;/h2-5,10-11H,1,6-9,12-13,28H2;1H
• InChIKey: NYYYAFKAHRIPJW-UHFFFAOYSA-N
• SMILES: C1CC12C3=C(C=C(C=C3)F)N(C2=O)CC4=NC5=C(N4CCCC(F)(F)F)C=CC(=C5)CN.Cl

Sisunatovir HCl (Cat No.:I036317) is a compound under investigation for its antiviral properties, specifically against respiratory viruses. Acting as a selective antagonist of the human voltage-gated sodium channel Nav1.7, it has shown potential analgesic effects in preclinical studies. Additionally, Sisunatovir HCl exhibits inhibitory activity against the respiratory syncytial virus (RSV) and is being studied for its therapeutic potential in respiratory viral infections.

Reference

1: Cockerill GS, Angell RM, Bedernjak A, Chuckowree I, Fraser I, Gascon-Simorte J, Gilman MSA, Good JAD, Harland R, Johnson SM, Ludes-Meyers JH, Littler E, Lumley J, Lunn G, Mathews N, McLellan JS, Paradowski M, Peeples ME, Scott C, Tait D, Taylor G, Thom M, Thomas E, Villalonga Barber C, Ward SE, Watterson D, Williams G, Young P, Powell K. Discovery of Sisunatovir (RV521), an Inhibitor of Respiratory Syncytial Virus Fusion. J Med Chem. 2021 Mar 17. doi: 10.1021/acs.jmedchem.0c01882. Epub ahead of print. PMID: 33729773.
2: DeVincenzo J, Tait D, Efthimiou J, Mori J, Kim YI, Thomas E, Wilson L, Harland R, Mathews N, Cockerill S, Powell K, Littler E. A Randomized, Placebo- Controlled, Respiratory Syncytial Virus Human Challenge Study of the Antiviral Efficacy, Safety, and Pharmacokinetics of RV521, an Inhibitor of the RSV-F Protein. Antimicrob Agents Chemother. 2020 Jan 27;64(2):e01884-19. doi: 10.1128/AAC.01884-19. PMID: 31712214; PMCID: PMC6985722.