Sisunatovir free base

• CAT Number: I036316
• CAS Number: 1903763-82-5
• Molecular Formula: C23H22F4N4O
• Molecular Weight: 446.45
• Purity: 98%
• Solubility: Soluble in DMSO
• Storage: Store at -20°C
• IUPAC Name: 1'-((5-(aminomethyl)-1-(4,4,4-trifluorobutyl)-1H-benzo[d]imidazol-2-yl)methyl)-6'-fluorospiro[cyclopropane-1,3'-indolin]-2'-one
• InChI: InChI=1S/C23H22F4N4O/c24-15-3-4-16-19(11-15)31(21(32)22(16)7-8-22)13-20-29-17-10-14(12-28)2-5-18(17)30(20)9-1-6-23(25,26)27/h2-5,10-11H,1,6-9,12-13,28H2
• InChIKey: JOPCJJSYRPUEDS-UHFFFAOYSA-N
• SMILES: O=C1C2(CC2)C3=C(C=C(F)C=C3)N1CC4=NC5=C(N4CCCC(F)(F)F)C=CC(CN)=C5

Sisunatovir free base（Cat No.:I036316）, is a promising antiviral compound. It acts as an inhibitor of the fusion protein HR1 domain, specifically targeting respiratory syncytial virus (RSV) infections. Through its potent antiviral activity against RSV, Sisunatovir free base shows potential as a therapeutic option. It represents a new approach to combat RSV, a respiratory viral infection.

Reference

1: Cockerill GS, Angell RM, Bedernjak A, Chuckowree I, Fraser I, Gascon-Simorte J, Gilman MSA, Good JAD, Harland R, Johnson SM, Ludes-Meyers JH, Littler E, Lumley J, Lunn G, Mathews N, McLellan JS, Paradowski M, Peeples ME, Scott C, Tait D, Taylor G, Thom M, Thomas E, Villalonga Barber C, Ward SE, Watterson D, Williams G, Young P, Powell K. Discovery of Sisunatovir (RV521), an Inhibitor of Respiratory Syncytial Virus Fusion. J Med Chem. 2021 Mar 17. doi: 10.1021/acs.jmedchem.0c01882. Epub ahead of print. PMID: 33729773.
2: DeVincenzo J, Tait D, Efthimiou J, Mori J, Kim YI, Thomas E, Wilson L, Harland R, Mathews N, Cockerill S, Powell K, Littler E. A Randomized, Placebo- Controlled, Respiratory Syncytial Virus Human Challenge Study of the Antiviral Efficacy, Safety, and Pharmacokinetics of RV521, an Inhibitor of the RSV-F Protein. Antimicrob Agents Chemother. 2020 Jan 27;64(2):e01884-19. doi: 10.1128/AAC.01884-19. PMID: 31712214; PMCID: PMC6985722.