Sisapronil

• CAT Number: I009358
• CAS Number: 856225-89-3
• Molecular Formula: C15H6Cl2F8N4
• Molecular Weight: 465.128
• Purity: ≥95%
• Synonyms: Sisapronil; PF-0241851; PF 0241851; PF0241851.;1H-Pyrazole-3-carbonitrile, 5-amino-1-(2,6-dichloro-4-(trifluoromethyl)phenyl)-4-(2,2-difluoro-1-(trifluoromethyl)cyclopropyl)-
• Solubility: Soluble in DMSO
• Storage: 0 - 4 °C for short term, or -20 °C for long term
• IUPAC Name: 5-amino-1-[2,6-dichloro-4-(trifluoromethyl)phenyl]-4-[2,2-difluoro-1-(trifluoromethyl)cyclopropyl]pyrazole-3-carbonitrile
• InChI: InChI=1S/C15H6Cl2F8N4/c16-6-1-5(14(20,21)22)2-7(17)10(6)29-11(27)9(8(3-26)28-29)12(15(23,24)25)4-13(12,18)19/h1-2H,4,27H2
• InChIKey: VBAVKJPWXSLDSG-UHFFFAOYSA-N
• SMILES: C1C(C1(F)F)(C2=C(N(N=C2C#N)C3=C(C=C(C=C3Cl)C(F)(F)F)Cl)N)C(F)(F)F

Sisapronil, also known as PF-0241851, is an ectoparasiticide and a member of the phenylpyrazole class of antiparasitics.

Reference

1: World Health Organization.. Evaluation of certain veterinary drug residues in food. Eighty-first report of the Joint FAO/WHO Expert Committee on Food Additives. World Health Organ Tech Rep Ser. 2016;(997):1-110. PubMed PMID: 27509597.2:Riviere JE, Brooks JD, Collard WT, Deng J, de Rose G, Mahabir SP, Merritt DA, Marchiondo AA. Prediction of formulation effects on dermal absorption of topically applied ectoparasiticides dosed in vitro on canine and porcine skin using a mixture-adjusted quantitative structure permeability relationship. J Vet Pharmacol Ther. 2014 Oct;37(5):435-44. doi: 10.1111/jvp.12121. PubMed PMID: 24649911.