Sirtuin-1 inhibitor 1

• CAT Number: I040544
• CAS Number: 945114-10-3
• Molecular Formula: C20H17N3O2
• Molecular Weight: 331.37
• Purity: ≥95%
• Synonyms: N-[4-(phenylcarbamoylamino)phenyl]benzamide
• InChI: InChI=1S/C20H17N3O2/c24-19(15-7-3-1-4-8-15)21-17-11-13-18(14-12-17)23-20(25)22-16-9-5-2-6-10-16/h1-14H,(H,21,24)(H2,22,23,25)
• InChIKey: OEASWMAWUWRMHZ-UHFFFAOYSA-N
• SMILES: C1=CC=C(C=C1)C(=O)NC2=CC=C(C=C2)NC(=O)NC3=CC=CC=C3

Sirtuin-1 inhibitor 1(CAT: I040544) is a selective small-molecule inhibitor of SIRT1, a NAD⁺-dependent class III histone deacetylase involved in regulating gene expression, metabolism, aging, and stress responses. By blocking SIRT1 enzymatic activity, this compound promotes acetylation of key substrates such as p53, FOXO, and NF-κB, thereby modulating cellular pathways related to apoptosis, inflammation, and metabolic control. Sirtuin-1 inhibitor 1 is a valuable tool for dissecting the role of SIRT1 in disease contexts, including cancer, neurodegeneration, and metabolic disorders. It supports both in vitro and in vivo studies aimed at understanding epigenetic regulation and developing targeted SIRT1-based therapeutic strategies.