SIRT2 Inhibitor

• CAT Number: I003519
• CAS Number: 420831-40-9
• Molecular Formula: C₁₉H₂₁BrN₂O₃S
• Molecular Weight: 437.35
• Purity: ≥95%
• Target: Sirtuin
• Solubility: 10 mM in DMSO
• Storage: Store at -20°C
• InChI: InChI=1S/C19H21BrN2O3S/c20-16-8-6-9-17(14-16)21-19(23)15-7-5-10-18(13-15)26(24,25)22-11-3-1-2-4-12-22/h5-10,13-14H,1-4,11-12H2,(H,21,23)
• InChIKey: IYAYHZZWYNXHEQ-UHFFFAOYSA-N
• SMILES: C1CCCN(CC1)S(=O)(=O)C2=CC=CC(=C2)C(=O)NC3=CC(=CC=C3)Br

SIRT2 Inhibitor(CAT: I003519)(AK-7) is a highly selective and brain-permeable inhibitor of SIRT2, a class III histone deacetylase enzyme involved in various cellular processes. With its unique neuroprotective properties, AK-7 has shown promise in preclinical studies targeting neurodegenerative conditions, such as Huntington’s disease. By inhibiting SIRT2, AK-7 may modulate key pathways associated with disease progression and offer therapeutic potential for the treatment of neurodegenerative disorders.

Reference

1:Aging-related 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurochemial and behavioral deficits and redox dysfunction: improvement by AK-7. Guan Q, Wang M, Chen H, Yang L, Yan Z, Wang X.Exp Gerontol. 2016 Sep;82:19-29. doi: 10.1016/j.exger.2016.05.011. Epub 2016 May 25. PMID: 27235848 2:Aging-related rotenone-induced neurochemical and behavioral deficits: role of SIRT2 and redox imbalance, and neuroprotection by AK-7. Wang X, Guan Q, Wang M, Yang L, Bai J, Yan Z, Zhang Y, Liu Z.Drug Des Devel Ther. 2015 May 7;9:2553-63. doi: 10.2147/DDDT.S81539. eCollection 2015. PMID: 26089639 Free PMC Article3:The sirtuin 2 inhibitor AK-7 is neuroprotective in Huntington/’s disease mouse models. Chopra V, Quinti L, Kim J, Vollor L, Narayanan KL, Edgerly C, Cipicchio PM, Lauver MA, Choi SH, Silverman RB, Ferrante RJ, Hersch S, Kazantsev AG.Cell Rep. 2012 Dec 27;2(6):1492-7. doi: 10.1016/j.celrep.2012.11.001. Epub 2012 Nov 29. PMID: 23200855 Free PMC Article