Sinoporphyrin sodium

• CAT Number: I009357
• CAS Number: 1820582-41-9
• Molecular Formula: C68H66N8Na4O98-
• Molecular Weight: 1231.2865
• Purity: ≥95%
• Synonyms: Sinoporphyrin sodium; DVDMS; sinoporphyrin; DVDMS Free;3,3/’-(7-(1-(1-(13,17-bis(2-carboxylatoethyl)-3,8,12,18-tetramethyl-7-vinylporphyrin-2-yl)ethoxy)ethyl)-3,8,13,17-tetramethyl-12-vinylporphyrin-2,18-diyl)dipropionate tetrasodium
• Solubility: Soluble in DMSO
• Storage: 0 - 4 °C for short term, or -20 °C for long term
• InChI: InChI=1S/C68H70N8O9.4Na/c1-13-41-31(3)47-23-49-33(5)43(15-19-63(77)78)57(71-49)29-59-45(17-21-65(81)82)35(7)51(73-59)27-61-67(37(9)53(75-61)25-55(41)69-47)39(11)85-40(12)68-38(10)54-26-56-42(14-2)32(4)48(70-56)24-50-34(6)44(16-20-64(79)80)58(72-50)30-60-4
• InChIKey: DVJUUYCXZVLGRJ-FLLOIMQSSA-J
• SMILES: C=CC1=C(C)/C2=C/C(C(C)=C/3CCC([O-])=O)=NC3=C/C4=C(CCC([O-])=O)C(C)=C(/C=C5C(C(OC(C6=C(C)/C7=C/C8=N/C(C(C)=C8C=C)=CC9=C(C)C(CCC([O-])=O)=C(/C=C%10C(CCC([O-])=O)=C(C)C(/C=C6N7)=N/%10)N9)C)C)=C(C)C(/C=C1N2)=N/5)N4.[Na-].[Na-].[Na-].[Na-]

Sinoporphyrin sodium, also known as DVDMS, is a photosensitizer that shows potential in both sonodynamic therapy and photodynamic therapy. Sinoporphyrin sodium significantly suppressed cell proliferation, promoted early apoptotic response, triggered collapse of F-actin filaments and inhibited cell migration. Sinoporphyrin sodium potentially a treatment for cancer.

Reference

1:Preclinical Study of Antineoplastic Sinoporphyrin Sodium-PDT via In Vitro and In Vivo Models. Shi R, Li C, Jiang Z, Li W, Wang A, Wei J.Molecules. 2017 Jan 11;22(1). pii: E112. doi: 10.3390/molecules22010112. PMID: 28085075 Free Article2:Comparative study of two kinds of repeated photodynamic therapy strategies in breast cancer by using a sensitizer, sinoporphyrin sodium. Xiong W, Wang X, Hu J, Liu Y, Liu Q, Wang P.J Photochem Photobiol B. 2016 Jul;160:299-305. doi: 10.1016/j.jphotobiol.2016.04.024. Epub 2016 Apr 25. PMID: 27162175 3:Sinoporphyrin sodium triggered sono-photodynamic effects on breast cancer both in vitro and in vivo. Liu Y, Wang P, Liu Q, Wang X.Ultrason Sonochem. 2016 Jul;31:437-48. doi: 10.1016/j.ultsonch.2016.01.038. Epub 2016 Jan 29. PMID: 26964970 4:The antibacterial effect of sinoporphyrin sodium photodynamic therapy on Staphylococcus aureus planktonic and biofilm cultures. Mai B, Wang X, Liu Q, Leung AW, Wang X, Xu C, Wang P.Lasers Surg Med. 2016 Apr;48(4):400-8. doi: 10.1002/lsm.22468. Epub 2016 Jan 8. PMID: 26749227 5:Sinoporphyrin sodium mediated photodynamic therapy inhibits the migration associated with collapse of F-actin filaments cytoskeleton in MDA-MB-231 cells. Wu L, Wang X, Liu Q, Wingnang Leung A, Wang P, Xu C.Photodiagnosis Photodyn Ther. 2016 Mar;13:58-65. doi: 10.1016/j.pdpdt.2015.12.008. Epub 2015 Dec 29. PMID: 26742781 6:Microbubbles Enhance the Antitumor Effects of Sinoporphyrin Sodium Mediated Sonodynamic Therapy both In Vitro and In Vivo. Wang H, Wang P, Li L, Zhang K, Wang X, Liu Q.Int J Biol Sci. 2015 Nov 15;11(12):1401-9. doi: 10.7150/ijbs.12802. eCollection 2015. PMID: 26681919 Free PMC Article7:Analysis of the in vivo and in vitro effects of photodynamic therapy on breast cancer by using a sensitizer, sinoporphyrin sodium. Wang X, Hu J, Wang P, Zhang S, Liu Y, Xiong W, Liu Q.Theranostics. 2015 Apr 6;5(7):772-86. doi: 10.7150/thno.10853. eCollection 2015. PMID: 25897341 Free PMC Article8:A safety study of a novel photosensitizer, sinoporphyrin sodium, for photodynamic therapy in Beagle dogs. Lin N, Li C, Wang Z, Zhang J, Ye X, Gao W, Wang A, Jin H, Wei J.Photochem Photobiol Sci. 2015 Apr;14(4):815-32. doi: 10.1039/c4pp00463a. PMID: 25671327 9:Enhanced fluorescence imaging guided photodynamic therapy of sinoporphyrin sodium loaded graphene oxide. Yan X, Niu G, Lin J, Jin AJ, Hu H, Tang Y, Zhang Y, Wu A, Lu J, Zhang S, Huang P, Shen B, Chen X.Biomaterials. 2015 Feb;42:94-102. doi: 10.1016/j.biomaterials.2014.11.040. Epub 2014 Dec 15. PMID: 25542797 Free PMC Article10:Antitumor effect of sinoporphyrin sodium-mediated photodynamic therapy on human esophageal cancer Eca-109 cells. Hu J, Wang X, Liu Q, Zhang K, Xiong W, Xu C, Wang P, Leung AW.Photochem Photobiol. 2014 Nov-Dec;90(6):1404-12. doi: 10.1111/php.12333. Epub 2014 Oct 7. PMID: 25142812