Simvastatin

• CAT Number: A000513
• CAS Number: 79902-63-9
• Molecular Formula: C₂₅H₃₈O₅
• Molecular Weight: 418.57
• Purity: ≥95%
• Target: HMG-CoA Reductase
• Solubility: >18.3mg/mL in DMSO
• Storage: -20°C
• InChI: InChI=1S/C25H38O5/c1-6-25(4,5)24(28)30-21-12-15(2)11-17-8-7-16(3)20(23(17)21)10-9-19-13-18(26)14-22(27)29-19/h7-8,11,15-16,18-21,23,26H,6,9-10,12-14H2,1-5H3/t15-,16-,18+,19+,20-,21-,23-/m0/s1
• InChIKey: RYMZZMVNJRMUDD-HGQWONQESA-N
• SMILES: CCC(C)(C)C(=O)OC1CC(C=C2C1C(C(C=C2)C)CCC3CC(CC(=O)O3)O)C

Simvastatin is a competitive inhibitor of HMG-CoA reductase. This compound has been shown to modulate purified bovine pituitary 20 S proteasome via mild stimulation of chymotrypsin-like activity and inhibition of peptidylglutamylpeptide hydrolyzing activity. Simvastatin is marketed under the trade name Zocor™ and is often prescribed in combination with ezetimibe to treat dyslipidemia. This drug combination is known commercially as Vytorin or Inegy.

Reference

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