Sildenafil citrate

• CAT Number: A000759
• CAS Number: 171599-83-0
• Molecular Formula: C₂₂H₃₀N₆O₄S.C₆H₈O₇
• Molecular Weight: 666.71
• Purity: ≥95%
• Target: PDE
• Solubility: >25.4mg/mL in DMSO
• Storage: 3 years -20C powder
• IUPAC Name: 5-[2-ethoxy-5-(4-methylpiperazin-1-yl)sulfonylphenyl]-1-methyl-3-propyl-6H-pyrazolo[4,3-d]pyrimidin-7-one;2-hydroxypropane-1,2,3-tricarboxylic acid
• InChI: InChI=1S/C22H30N6O4S.C6H8O7/c1-5-7-17-19-20(27(4)25-17)22(29)24-21(23-19)16-14-15(8-9-18(16)32-6-2)33(30,31)28-12-10-26(3)11-13-28;7-3(8)1-6(13,5(11)12)2-4(9)10/h8-9,14H,5-7,10-13H2,1-4H3,(H,23,24,29);13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)
• InChIKey: DEIYFTQMQPDXOT-UHFFFAOYSA-N
• SMILES: CCCC1=NN(C2=C1NC(=NC2=O)C3=C(C=CC(=C3)S(=O)(=O)N4CCN(CC4)C)OCC)C.C(C(=O)O)C(CC(=O)O)(C(=O)O)O

Sildenafil citrate (Cat No.:A000759) is a potent and reversible selective inhibitor of PDE type V, which effectively blocks the hydrolysis of cGMP (Ki∼3nM). sildenafil exhibits high affinity for PDE types V and VI with inhibition constants (Ki) of ∼3.5 and 33nM, respectively.

Overview of Clinical Research

Sildenafil Citrate is a type 5 cyclic nucleotide phosphodiesterase inhibitor. It has been granted the orphan drug status in Pulmonary arterial hypertension; Heart failure and Pulmonary hypertension.

Reference

1.Nehra A, et al. World J Urol, 2001, 19(1), 40-45.

2.Shukla N, et al. Eur J Pharmacol, 2005, 517(3), 224-231.

3.Mulhall JP, et al. J Sex Med, 2008, 5(5), 1126-1136.