Sigma-1 receptor antagonist 3（Cat No.:I017956）is a selective small-molecule inhibitor targeting the sigma-1 receptor, a chaperone protein located at the endoplasmic reticulum–mitochondria interface. This receptor regulates calcium signaling, ion channel activity, and neuroprotective pathways. By blocking sigma-1 receptor activity, antagonist 3 disrupts its modulatory effects on neurotransmission and cellular stress responses. Preclinical research indicates its potential to reduce neuropathic pain, attenuate addictive behaviors, and influence neurodegenerative processes. Sigma-1 receptor antagonist 3 is widely applied as a pharmacological probe for investigating sigma-1 receptor function and therapeutic relevance.