For research use only. Not for therapeutic Use.
SHP836(CAT: I017633) is a selective allosteric inhibitor of SHP2, a key protein tyrosine phosphatase involved in growth factor, cytokine, and oncogenic signaling. It exhibits an IC₅₀ of 12 μM against full-length SHP2. SHP836 functions by stabilizing SHP2 in its inactive closed conformation, where the catalytic site remains blocked and inaccessible to substrates, thereby suppressing downstream signaling pathways. As dysregulated SHP2 activity contributes to multiple cancers and developmental disorders, SHP836 provides a valuable tool for investigating SHP2 regulation, RAS/MAPK signaling, and therapeutic targeting strategies in oncology and immune-related diseases.
| CAS Number | 1957276-35-5 |
| Synonyms | 5-(2,3-dichlorophenyl)-2-[(3S,5R)-3,5-dimethylpiperazin-1-yl]pyrimidin-4-amine |
| Molecular Formula | C16H19Cl2N5 |
| Purity | ≥95% |
| IUPAC Name | 5-(2,3-dichlorophenyl)-2-[(3S,5R)-3,5-dimethylpiperazin-1-yl]pyrimidin-4-amine |
| InChI | InChI=1S/C16H19Cl2N5/c1-9-7-23(8-10(2)21-9)16-20-6-12(15(19)22-16)11-4-3-5-13(17)14(11)18/h3-6,9-10,21H,7-8H2,1-2H3,(H2,19,20,22)/t9-,10+ |
| InChIKey | SKFRRNOLFFQBQU-AOOOYVTPSA-N |
| SMILES | CC1CN(CC(N1)C)C2=NC=C(C(=N2)N)C3=C(C(=CC=C3)Cl)Cl |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
