SGD-1882

• CAT Number: I013233
• CAS Number: 1222490-34-7
• Molecular Formula: C₄₂H₃₉N₅O₇
• Molecular Weight: 725.79
• Purity: ≥95%
• Target: ADC Cytotoxin
• Solubility: DMSO
• IUPAC Name: (6aS)-3-[3-[[(6aS)-2-methoxy-8-(4-methoxyphenyl)-11-oxo-6a,7-dihydropyrrolo[2,1-c][1,4]benzodiazepin-3-yl]oxy]propoxy]-8-(4-aminophenyl)-2-methoxy-6a,7-dihydropyrrolo[2,1-c][1,4]benzodiazepin-11-one
• InChI: InChI=1S/C42H39N5O7/c1-50-32-11-7-26(8-12-32)28-16-31-22-45-36-20-40(38(52-3)18-34(36)42(49)47(31)24-28)54-14-4-13-53-39-19-35-33(17-37(39)51-2)41(48)46-23-27(15-30(46)21-44-35)25-5-9-29(43)10-6-25/h5-12,17-24,30-31H,4,13-16,43H2,1-3H3/t30-,31-/m0/s1
• InChIKey: OMRPLUKQNWNZAV-CONSDPRKSA-N
• SMILES: COC1=CC=C(C=C1)C2=CN3C(C2)C=NC4=CC(=C(C=C4C3=O)OC)OCCCOC5=C(C=C6C(=C5)N=CC7CC(=CN7C6=O)C8=CC=C(C=C8)N)OC

SGD-1882（Cat No.:I013233） is a potent cytotoxic compound that acts as a payload for antibody-drug conjugates (ADCs). It belongs to the class of pyrrolobenzodiazepine (PBD) dimers, which are known for their ability to crosslink DNA in the minor groove. Through this mechanism, SGD-1882 induces DNA damage and disrupts DNA replication and transcription in target cells. Its cytotoxic properties make it a promising candidate for use in ADCs, where it can specifically deliver its DNA-crosslinking payload to cancer cells, thereby enhancing the therapeutic efficacy of the conjugate.

Reference

[1]. Eunhee G. Kim, et al. Strategies and Advancement in Antibody-Drug Conjugate Optimization for Targeted Cancer Therapeutics. Biomol Ther (Seoul). 2015 Nov; 23(6): 493-509.[2]. Dowdy Jackson, et al. Using the Lessons Learned From the Clinic to Improve the Preclinical Development of Antibody Drug Conjugates. Pharm Res. 2015; 32(11): 3458-3469.