SGC-CK2-1

• CAT Number: I036276
• CAS Number: 2470424-39-4
• Molecular Formula: C21H22N6O
• Molecular Weight: 374.448
• Purity: 98%
• Solubility: Soluble in DMSO
• Storage: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
• IUPAC Name: N-(5-((3-cyano-7-(cyclopropylamino)pyrazolo[1,5-a]pyridin-5-yl)amino)-2-methylphenyl)propionamide
• InChI: InChI=1S/C21H22N6O/c1-3-21(28)26-18-8-16(5-4-13(18)2)24-17-9-19-14(11-22)12-23-27(19)20(10-17)25-15-6-7-15/h4-5,8-10,12,15,24-25H,3,6-7H2,1-2H3,(H,26,28)
• InChIKey: PGNTUMFXKVRXNQ-UHFFFAOYSA-N
• SMILES: CC1=C(NC(CC)=O)C=C(NC2=CC3=C(C#N)C=NN3C(NC4CC4)=C2)C=C1

SGC-CK2-1 (CAT: I036276) is a potent and selective inhibitor of the protein kinase CK2 (Casein Kinase 2). CK2 is a serine/threonine kinase that regulates various cellular processes, including cell growth, proliferation, and survival. SGC-CK2-1 has been developed as a research tool to investigate the role of CK2 in cellular signaling pathways and to explore its potential as a therapeutic target in diseases such as cancer and neurodegenerative disorders. By selectively inhibiting CK2 activity, SGC-CK2-1 may modulate the dysregulated signaling pathways associated with these diseases and provide insights into the development of novel therapeutic strategies.

Reference

1: Licciardello MP, Workman P. A New Chemical Probe Challenges the Broad Cancer Essentiality of CK2. Trends Pharmacol Sci. 2021 May;42(5):313-315. doi: 10.1016/j.tips.2021.02.002. Epub 2021 Mar 23. PMID: 33771354.
2: Wells CI, Drewry DH, Pickett JE, Tjaden A, Krämer A, Müller S, Gyenis L, Menyhart D, Litchfield DW, Knapp S, Axtman AD. Development of a potent and selective chemical probe for the pleiotropic kinase CK2. Cell Chem Biol. 2021 Apr 15;28(4):546-558.e10. doi: 10.1016/j.chembiol.2020.12.013. Epub 2021 Jan 22. PMID: 33484635.