Sertindole

• CAT Number: I000321
• CAS Number: 106516-24-9
• Molecular Formula: C24H26ClFN4O
• Molecular Weight: 440.94
• Purity: ≥95%
• Target: Multi-target
• Solubility: 10 mM in DMSO
• Storage: 3 years -20C powder
• IUPAC Name: 1-[2-[4-[5-chloro-1-(4-fluorophenyl)indol-3-yl]piperidin-1-yl]ethyl]imidazolidin-2-one
• InChI: InChI=1S/C24H26ClFN4O/c25-18-1-6-23-21(15-18)22(16-30(23)20-4-2-19(26)3-5-20)17-7-10-28(11-8-17)13-14-29-12-9-27-24(29)31/h1-6,15-17H,7-14H2,(H,27,31)
• InChIKey: GZKLJWGUPQBVJQ-UHFFFAOYSA-N
• SMILES: C1CN(CCC1C2=CN(C3=C2C=C(C=C3)Cl)C4=CC=C(C=C4)F)CCN5CCNC5=O

Sertindole (CAT: I000321) is an atypical antipsychotic medication primarily used to treat schizophrenia. It belongs to the class of drugs known as serotonin-dopamine antagonists. Sertindole acts by blocking the binding of serotonin and dopamine to their respective receptors in the brain, helping to normalize neurotransmitter activity and alleviate symptoms of psychosis. It has been shown to be effective in reducing positive and negative symptoms of schizophrenia.

Overview of Clinical Research

Sertindole is an  alpha 1 adrenergic receptor antagonist and a dopamine D2 receptor antagonist.

Reference

1:Successful Use of Sertindole for Severe Behavioral Dyscontrol in a Pediatric Case of Syndromic Autism Spectrum Disorder. Naguy A.J Child Adolesc Psychopharmacol. 2017 Mar 15. doi: 10.1089/cap.2016.0182. [Epub ahead of print] PMID: 28296430
2:[The chemical toxicological analysis of sertindole]. Remezova IP, Lazaryan DS, Voronkov AV, Avramenko NS, Maksimenko TI, Sanzhieva DY.Sud Med Ekspert. 2016 Jan-Feb;59(1):35-9. Russian. PMID: 27030096
3:Comparison of phencyclidine-induced spatial learning and memory deficits and reversal by sertindole and risperidone between Lister Hooded and Wistar rats. Ihalainen J, Savolainen K, Tanila H, Forsberg MM.Behav Brain Res. 2016 May 15;305:140-7. doi: 10.1016/j.bbr.2016.02.032. Epub 2016 Mar 3. PMID: 26940605
4:Micelle enhanced and native spectrofluorimetric methods for determination of sertindole using sodium dodecyl sulfate as sensitizing agent. El-Kosasy AM, Hussein LA, Sedki NG, Salama NN.Spectrochim Acta A Mol Biomol Spectrosc. 2016 Jan 15;153:422-7. doi: 10.1016/j.saa.2015.08.040. Epub 2015 Sep 1. PMID: 26356788
5:Efficacy and safety of sertindole in schizophrenia: a clinical review. Zoccali RA, Bruno A, Muscatello MR.J Clin Psychopharmacol. 2015 Jun;35(3):286-95. doi: 10.1097/JCP.0000000000000305. Review. PMID: 25830594
6:QT dynamics during treatment with sertindole. Nielsen J, Wang F, Graff C, Kanters JK.Ther Adv Psychopharmacol. 2015 Feb;5(1):26-31. doi: 10.1177/2045125314560738. PMID: 25653828 Free PMC Article
7:Cardiac effects of sertindole and quetiapine: analysis of ECGs from a randomized double-blind study in patients with schizophrenia. Nielsen J, Matz J, Mittoux A, Polcwiartek C, Struijk JJ, Toft E, Kanters JK, Graff C.Eur Neuropsychopharmacol. 2015 Mar;25(3):303-11. doi: 10.1016/j.euroneuro.2014.12.005. Epub 2015 Jan 3. PMID: 25583364
8:Sertindole in schizophrenia: efficacy and safety issues. Muscatello MR, Bruno A, Micali Bellinghieri P, Pandolfo G, Zoccali RA.Expert Opin Pharmacother. 2014 Sep;15(13):1943-53. doi: 10.1517/14656566.2014.947960. Epub 2014 Aug 1. Review. PMID: 25084209
9:Comparison of the effects of Sertindole and Olanzapine on Cognition (SEROLA): a double-blind randomized 12-week study of patients diagnosed with schizophrenia. Ernst Nielsen R, Odur F, Ostergaard T, Munk-Jørgensen P, Nielsen J.Ther Adv Psychopharmacol. 2014 Feb;4(1):4-14. doi: 10.1177/2045125313499065. PMID: 24490025 Free PMC Article
10:[Acute poisoning with sertindole–a case report]. Waldman W, Kaletha K, Sein Anand J.Przegl Lek. 2013;70(8):669-70. Polish. PMID: 24466716