Sertaconazole nitrate

  • CAT Number: A001135
  • CAS Number: 99592-39-9
  • Molecular Formula: C20H15Cl3N2OS • HNO3
  • Molecular Weight: 500.8
  • Purity: ≥95%
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Sertaconazole nitrate is a topical broad-spectrum antifungal that is developed to provide an additional agent for the treatment of superficial cutaneous and mucosal infections. Sertaconazole nitrate may also inhibit endogenous respiration, interact with membrane phospholipids, inhibit the transformation of yeasts to mycelial forms, inhibit purine uptake, and impair triglyceride and/or phospholipid biosynthesis.

Catalog Number A001135
CAS Number 99592-39-9
Molecular Formula

C20H15Cl3N2OS • HNO3

Purity 95%
Storage -20°C
InChIKey HAAITRDZHUANGT-UHFFFAOYSA-N
Reference

</br>1:Sertaconazole nitrate loaded nanovesicular systems for targeting skin fungal infection: in-vitro, ex-vivo and in-vivo evaluation. Abdellatif MM, Khalil IA, Khalil MAF.Int J Pharm. 2017 May 15. pii: S0378-5173(17)30441-6. doi: 10.1016/j.ijpharm.2017.05.029. [Epub ahead of print] PMID: 28522423 </br>2:Investigation of the Dermal Absorption and Irritation Potential of Sertaconazole Nitrate Anhydrous Gel. Manian M, Madrasi K, Chaturvedula A, Banga AK.Pharmaceutics. 2016 Jul 7;8(3). pii: E21. doi: 10.3390/pharmaceutics8030021. PMID: 27399763 Free PMC Article</br>3:Fabrication and Characterization of Sertaconazole Nitrate Microsponge as a Topical Drug Delivery System. Pande VV, Kadnor NA, Kadam RN, Upadhye SA.Indian J Pharm Sci. 2015 Nov-Dec;77(6):675-80. PMID: 26997694 Free PMC Article</br>4:Design expert assisted formulation of topical bioadhesive gel of sertaconazole nitrate. Pande V, Patel S, Patil V, Sonawane R.Adv Pharm Bull. 2014;4(2):121-30. doi: 10.5681/apb.2014.019. Epub 2013 Dec 24. PMID: 24511475 Free PMC Article</br>5:Efficacy and Safety of Terbinafine Hydrochloride 1% Cream vs. Sertaconazole Nitrate 2% Cream in Tinea Corporis and Tinea Cruris: A Comparative Therapeutic Trial. Choudhary S, Bisati S, Singh A, Koley S.Indian J Dermatol. 2013 Nov;58(6):457-60. doi: 10.4103/0019-5154.119958. PMID: 24249898 Free PMC Article</br>6:Treatment of interdigital tinea pedis: once-daily therapy with sertaconazole nitrate. Weinberg JM, Koestenblatt EK.J Drugs Dermatol. 2011 Oct;10(10):1135-40. PMID: 21968663 </br>7:An open-label study of the safety and efficacy of sertaconazole nitrate in the treatment of seborrheic dermatitis. Elewski BE, Cantrell WC.J Drugs Dermatol. 2011 Aug;10(8):895-9. PMID: 21818511 </br>8:Sertaconazole nitrate shows fungicidal and fungistatic activities against Trichophyton rubrum, Trichophyton mentagrophytes, and Epidermophyton floccosum, causative agents of tinea pedis. Carrillo-Muñoz AJ, Tur-Tur C, Cárdenes DC, Estivill D, Giusiano G.Antimicrob Agents Chemother. 2011 Sep;55(9):4420-1. doi: 10.1128/AAC.00219-11. Epub 2011 Jul 11. PMID: 21746955 Free PMC Article</br>9:Induction of prostaglandin D2 through the p38 MAPK pathway is responsible for the antipruritic activity of sertaconazole nitrate. Kaur S, Sur R, Liebel FT, Southall MD.J Invest Dermatol. 2010 Oct;130(10):2448-56. doi: 10.1038/jid.2010.152. Epub 2010 May 27. PMID: 20505747 Free Article</br>10:Safety and efficacy of sertaconazole nitrate cream 2% in the treatment of tinea pedis interdigitalis: a subgroup analysis. Borelli C, Korting HC, Bödeker RH, Neumeister C.Cutis. 2010 Feb;85(2):107-11. PMID: 20349685

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