Seocalcitol

• CAT Number: I001312
• CAS Number: 134404-52-7
• Molecular Formula: C30H46O3
• Molecular Weight: 454.7
• Purity: ≥95%
• Synonyms: (1R,3S,5E)-5-[(2Z)-2-[(1R,3aS,7aR)-1-[(2R,3E,5E)-7-ethyl-7-hydroxynona-3,5-dien-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidenecyclohexane-1,3-diol
• Target: VD/VDR
• Solubility: in DMSO > 10 mM
• Storage: Store at -20°C
• InChIKey: LVLLALCJVJNGQQ-SEODYNFXSA-N

Seocalcitol (EB 1089; EB-1089)is a Vitamin D receptor (VDR) agonist; Seocalcitol is a analog of calcitriol.IC50 value:Target: VDRSeocalcitol(EB 1089; EB-1089) exhibits anti-tumor and anti-proliferative activity with reduced hypercalcemic effects. 60 times more potent in inhibiting MCF-7 cell growth in vitro. Reverses the effects of parathyroid hormone-related protein (PTHrP).

Reference

[1]. Ghous, Zahid; Akhter, Javed; Pourgholami, Mohammad H.; Morris, David L.Inhibition of hepatocellular cancer by EB1089: in vitro and in vivo study.Anticancer Research (2008), 28(6A), 3757-3761.
[2]. Lu, Lianjun; Qiu, Jianhua; Liu, Shunli; Luo, Wenjing. Vitamin D3 analogue EB1089 inhibits the proliferation of human laryngeal squamous carcinoma cells via p57. Molecular Cancer Therapeutics (2008), 7(5), 1268-1274.
[3]. Macejová D, Ondková S, Jakubíková L, Mlynar?íková A, Scsuková S, Li?ka J, Brtko J.MNU-induced mammary gland carcinogenesis: chemopreventive and therapeutic effects of vitamin D and Seocalcitol on selected regulatory vitamin D receptor pathways.Toxicol Lett. 2011 Nov 10;207(1):60-72. Epub 2011 Aug 5.
[4]. Bondza-Kibangou P, Millot C, El Khoury V, Millot JM.Antioxidants and doxorubicin supplementation to modulate CD14 expression and oxidative stress induced by vitamin D3 and seocalcitol in HL60 cells.Oncol Rep. 2007 Dec;18(6):1513-9.
[5]. Grove M, Müllertz A, Pedersen GP, Nielsen JL.Bioavailability of seocalcitol III. Administration of lipid-based formulations to minipigs in the fasted and fed state.Eur J Pharm Sci. 2007 May;31(1):8-15. Epub 2007 Feb 3.
[6]. T R J Evans,K W Colston,F J Lofts et al. A phase II trial of the vitamin D analogue Seocalcitol (EB1089) in patients with inoperable pancreatic cancer. British Journal of Cancer (2002) 86, 680-685.