For research use only. Not for therapeutic Use.
SENP1-IN-1（Cat No.:I044562）is a selective small-molecule inhibitor of SUMO-specific protease 1 (SENP1), an enzyme that regulates the removal of SUMO (Small Ubiquitin-like Modifier) groups from target proteins. By inhibiting SENP1, SENP1-IN-1 disrupts the deSUMOylation process, affecting protein stability, localization, and activity. This modulation influences key cellular pathways including cell cycle progression, stress responses, and oncogenic signaling. SENP1-IN-1 has shown potential in preclinical models for cancer therapy, where SENP1 is often overexpressed. It serves as a valuable chemical probe for studying SUMOylation dynamics and for developing targeted therapeutics in oncology and cellular stress regulation.
| CAS Number | 2416910-69-3 |
| Synonyms | (1S,2R,4aS,6aR,6aS,6bR,8aR,10S,12aR,14bS)-10-hydroxy-N-[2-[2-hydroxyethyl(methyl)amino]-2-oxoethyl]-1,2,6a,6b,9,9,12a-heptamethyl-2,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydro-1H-picene-4a-carboxamide |
| Molecular Formula | C35H58N2O4 |
| Purity | ≥95% |
| IUPAC Name | (1S,2R,4aS,6aR,6aS,6bR,8aR,10S,12aR,14bS)-10-hydroxy-N-[2-[2-hydroxyethyl(methyl)amino]-2-oxoethyl]-1,2,6a,6b,9,9,12a-heptamethyl-2,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydro-1H-picene-4a-carboxamide |
| InChI | InChI=1S/C35H58N2O4/c1-22-11-16-35(30(41)36-21-28(40)37(8)19-20-38)18-17-33(6)24(29(35)23(22)2)9-10-26-32(5)14-13-27(39)31(3,4)25(32)12-15-34(26,33)7/h9,22-23,25-27,29,38-39H,10-21H2,1-8H3,(H,36,41)/t22-,23+,25+,26-,27+,29+,32+,33-,34-,35+/m1/s1 |
| InChIKey | GYEWLVQWUVDKKH-SKHUFZRLSA-N |
| SMILES | C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)O)C)C)[C@@H]2[C@H]1C)C)C(=O)NCC(=O)N(C)CCO |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
