Pachymic acid

• CAT Number: I003007
• CAS Number: 29070-92-6
• Molecular Formula: C33H52O5
• Molecular Weight: 528.76
• Purity: ≥95%
• Solubility: 10 mM in DMSO
• Storage: Store at -20°C

Pachymic acid is a lanostrane-type triterpenoid, which possesses anti-emetic, anti-inflammatory, and anti-cancer properties.IC50 value:Target:In vitro: Pachymic acid exhibited anti-tumor effects in vitro accompanied by induction of G2/M phase arrest and apoptosis in NCI-H23 and NCI-H460 lung cancer cells. Pachymic acid induced reactive oxygen species (ROS) production, resulting in the activation of both c-Jun N-terminal kinase (JNK) and endoplasmic reticulum (ER) stress apoptotic pathways in lung cancer cells. Blockage of ROS production reversed pachymic acidinhibited-induced JNK and ER stress activation. Finally, pachymic acid inhibited the growth of NCI-H23 xenograft tumors without causing any host toxicity, and inhibited cell proliferation and induction of apoptosis of tumor cells in tumor xenograft tissues [1]. HO-8910 cells was treated with different concentrations of pachymic acid, pachymic acid could effectively inhibit the in vitro growth of HO-8910 cells in dose-dependent manners in 72 h, suppressed migration and invasion of HO-8910 cells in concentration-dependent manners at 24 h, caused the increased accumulation of G1 phase cells, and caused down-regulation of β-catenin and COX-2 and up-regulation of E-cadherin expression level [2].In vivo:

Reference

[1]. Jun Ma, et al. Pachymic acid induces apoptosis via activating ROS-dependent JNK and ER stress pathways in lung cancer cells. Cancer Cell Int. 2015; 15: 78.

[2]. Ai-Hua Gao, et al. Inhibition of ovarian cancer proliferation and invasion by pachymic acid. Int J Clin Exp Pathol. 2015; 8(2): 2235–2241.

[3]. Shujie Cheng, et al. Pachymic Acid Inhibits Growth and Induces Apoptosis of Pancreatic Cancer In Vitro and In Vivo by Targeting ER Stress. PLoS One. 2015; 10(4): e0122270.