SEA0400

• CAT Number: I002710
• CAS Number: 223104-29-8
• Molecular Formula: C21H19F2NO3
• Molecular Weight: 371.4
• Purity: ≥95%
• Target: 5-HT Receptor
• Solubility: DMSO: ≥ 32 mg/mL
• Storage: Store at -20°C
• IC50: 5-33 nM
• IUPAC Name: 2-[4-[(2,5-difluorophenyl)methoxy]phenoxy]-5-ethoxyaniline
• InChI: InChI=1S/C21H19F2NO3/c1-2-25-18-8-10-21(20(24)12-18)27-17-6-4-16(5-7-17)26-13-14-11-15(22)3-9-19(14)23/h3-12H,2,13,24H2,1H3
• InChIKey: YSUBLPUJDOWYDP-UHFFFAOYSA-N
• SMILES: CCOC1=CC(=C(C=C1)OC2=CC=C(C=C2)OCC3=C(C=CC(=C3)F)F)N

SEA0400 (Cat.No:I002710) is a selective inhibitor of the sodium/calcium exchanger (NCX), a protein involved in the regulation of intracellular calcium levels. It has been studied for its potential in cardiovascular research, specifically for its ability to protect cardiac tissue from ischemic injury. SEA0400 shows promise as a cardioprotective agent in preclinical studies.

Reference

1:Block of Na(+)/Ca(2+) exchanger by SEA0400 in human right atrial preparations from patients in sinus rhythm and in atrial fibrillation. Christ T, Kovács PP, Acsai K, Knaut M, Eschenhagen T, Jost N, Varró A, Wettwer E, Ravens U.Eur J Pharmacol. 2016 Oct 5;788:286-93. doi: 10.1016/j.ejphar.2016.06.050. Epub 2016 Jun 29. PMID: 27373849 2:Effects of renal Na+/Ca2+ exchanger 1 inhibitor (SEA0400) treatment on electrolytes, renal function and hemodynamics in rats. Yatabe MS, Yatabe J, Takano K, Sanada H, Kimura J, Watanabe T.Clin Exp Nephrol. 2015 Aug;19(4):585-90. doi: 10.1007/s10157-014-1053-3. Epub 2014 Nov 20. PMID: 25410661 3:The Na+/Ca2+ exchange inhibitor SEA0400 limits intracellular Ca2+ accumulation and improves recovery of ventricular function when added to cardioplegia. Egar J, Ali A, Howlett SE, Friesen CH, O/’Blenes S.J Cardiothorac Surg. 2014 Jan 8;9:11. doi: 10.1186/1749-8090-9-11. PMID: 24401610 Free PMC Article4:Effects of SEA0400 on arrhythmogenicity in a Langendorff-perfused 1-month myocardial infarction rabbit model. Chou CC, Chang PC, Wen MS, Lee HL, Chu Y, Baba A, Matsuda T, Yeh SJ, Wu D.Pacing Clin Electrophysiol. 2013 May;36(5):596-606. doi: 10.1111/pace.12091. Epub 2013 Feb 4. PMID: 23380010 5:Inhibition of the sodium-calcium exchanger via SEA0400 altered manganese-induced T1 changes in isolated perfused rat hearts. Chen Y, Payne K, Perara VS, Huang S, Baba A, Matsuda T, Yu X.NMR Biomed. 2012 Nov;25(11):1280-5. doi: 10.1002/nbm.2799. Epub 2012 Mar 21. PMID: 22434695 Free PMC Article6:SEA0400, a specific Na+/Ca2+ exchange inhibitor, prevents dopaminergic neurotoxicity in an MPTP mouse model of Parkinson/’s disease. Ago Y, Kawasaki T, Nashida T, Ota Y, Cong Y, Kitamoto M, Takahashi T, Takuma K, Matsuda T.Neuropharmacology. 2011 Dec;61(8):1441-51. doi: 10.1016/j.neuropharm.2011.08.041. Epub 2011 Sep 2. PMID: 21903118 7:The specific Na(+)/Ca(2+) exchange inhibitor SEA0400 prevents nitric oxide-induced cytotoxicity in SH-SY5Y cells. Nashida T, Takuma K, Fukuda S, Kawasaki T, Takahashi T, Baba A, Ago Y, Matsuda T.Neurochem Int. 2011 Aug;59(1):51-8. doi: 10.1016/j.neuint.2011.03.026. Epub 2011 Jun 6. PMID: 21672583 8:Assessing manganese efflux using SEA0400 and cardiac T1-mapping manganese-enhanced MRI in a murine model. Waghorn B, Yang Y, Baba A, Matsuda T, Schumacher A, Yanasak N, Hu TC.NMR Biomed. 2009 Oct;22(8):874-81. doi: 10.1002/nbm.1414. PMID: 19593760 9:Involvement of the Na(+)/Ca(2+) exchanger in the automaticity of guinea-pig pulmonary vein myocardium as revealed by SEA0400. Namekata I, Tsuneoka Y, Takahara A, Shimada H, Sugimoto T, Takeda K, Nagaharu M, Shigenobu K, Kawanishi T, Tanaka H.J Pharmacol Sci. 2009 May;110(1):111-6. Epub 2009 May 8. PMID: 19423954 Free Article10:SEA0400 fails to alter the magnitude of intracellular Ca2+ transients and contractions in Langendorff-perfused guinea pig heart. Szentandrássy N, Birinyi P, Szigeti G, Farkas A, Magyar J, Tóth A, Csernoch L, Varró A, Nánási PP.Naunyn Schmiedebergs Arch Pharmacol. 2008 Jul;378(1):65-71. doi: 10.1007/s00210-008-0296-5. Epub 2008 May 6. PMID: 18458877